S
Stefan Ambs
Researcher at National Institutes of Health
Publications - 192
Citations - 18892
Stefan Ambs is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 55, co-authored 162 publications receiving 17184 citations. Previous affiliations of Stefan Ambs include National University of Ireland & University of Maryland, Baltimore.
Papers
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
The chemical biology of nitric oxide: implications in cellular signaling.
Douglas D. Thomas,Lisa A. Ridnour,Jeff S. Isenberg,Wilmarie Flores-Santana,Christopher H. Switzer,Sonia Donzelli,Perwez Hussain,Cecilia Vecoli,Nazareno Paolocci,Stefan Ambs,Carol A. Colton,Curtis C. Harris,David D. Roberts,David A. Wink +13 more
TL;DR: Signal transduction and the chemical biology of NO in terms of the direct and indirect reactions are discussed, with general results that promote cell survival and proliferation, whereas higher levels favor cell cycle arrest, apoptosis, and senescence.
Journal ArticleDOI
MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer
Junfang Ji,Jiong Shi,Jiong Shi,Anuradha Budhu,Zhipeng Yu,Marshonna Forgues,Stephanie Roessler,Stefan Ambs,Yi Chen,Paul S. Meltzer,Carlo M. Croce,Lun Xiu Qin,Kwan Man,Chung Mau Lo,Joyce Man-Fong Lee,Irene Oi-Lin Ng,Jia Fan,Zhao-You Tang,Hui-Chuan Sun,Xin Wei Wang +19 more
TL;DR: The expression patterns of microRNAs in liver tissue differ between men and women with hepatocellular carcinoma, and the miR-26 expression status of such patients is associated with survival and response to adjuvant therapy with interferon alfa.
Journal ArticleDOI
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer.
Stefan Ambs,Robyn L. Prueitt,Ming Yi,Robert S. Hudson,Tiffany M. Howe,Fabio Petrocca,Tiffany A. Wallace,Chang Gong Liu,Stefano Volinia,George A. Calin,Harris G. Yfantis,Robert M. Stephens,Carlo M. Croce +12 more
TL;DR: Significant differences in microRNA abundance were found between organ-confined tumors and those with extraprostatic disease extension, and evidence that some microRNAs are androgen-regulated and that tumor micro RNAs influence transcript abundance of protein-coding target genes in the cancerous prostate was found.
Journal Article
Frequent Nitric Oxide Synthase-2 Expression in Human Colon Adenomas: Implication for Tumor Angiogenesis and Colon Cancer Progression
Stefan Ambs,William G. Merriam,William P. Bennett,Emanuela Felley-Bosco,Mofolusara O. Ogunfusika,S. M. Oser,Shawn Klein,Peter G. Shields,Timothy R. Billiar,Curtis C. Harris +9 more
TL;DR: Data from this study are consistent with the hypothesis that excessive NO production by NOS2 may contribute to the pathogenesis of colon cancer progression at the transition of colon adenoma to carcinoma in situ.