L
Lorne J. Hofseth
Researcher at University of South Carolina
Publications - 92
Citations - 9892
Lorne J. Hofseth is an academic researcher from University of South Carolina. The author has contributed to research in topics: Colitis & Inflammation. The author has an hindex of 50, co-authored 92 publications receiving 8977 citations. Previous affiliations of Lorne J. Hofseth include National Institutes of Health.
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Radical causes of cancer
TL;DR: Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved and highlights the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.
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p53: 25 years after its discovery.
TL;DR: The first 25 years of research on p53 are reviewed, which shows how this molecule continues to be studied intensively in biomedical research, including the fields of toxicology and pharmacology.
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p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
S. Perwez Hussain,Paul Amstad,Peijun He,Ana I. Robles,Shawn E. Lupold,Ichiro Kaneko,Masato Ichimiya,Sagar Sengupta,Leah E. Mechanic,Shu Okamura,Lorne J. Hofseth,Matthew Moake,Makoto Nagashima,Kathleen Forrester,Curtis C. Harris +14 more
TL;DR: A novel mechanism of p53-dependent apoptosis is identified in which p 53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress.
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Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast.
TL;DR: It is shown that postmenopausal HRT with E+P was associated with greater breast epithelial cell proliferation and breast epithelium density than E alone or no HRT, and breast proliferation was localized to the terminal duct-lobular unit of the breast, which is the site of development of most breast cancers.
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Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Lorne J. Hofseth,Shin'ichi Saito,S. Perwez Hussain,Michael Graham Espey,Katrina M. Miranda,Yuzuru Araki,Chamelli Jhappan,Yuichiro Higashimoto,Peijun He,Steven P. Linke,Martha Quezado,Irit Zurer,Varda Rotter,David A. Wink,Ettore Appella,Curtis C. Harris +15 more
TL;DR: In noncancerous colon tissues from patients with ulcerative colitis, inducible NO synthase protein levels were positively correlated with p53 serine 15 phosphorylation levels, and Immunostaining of HDM-2 and p21WAF1 was consistent with transcriptionally active p53.