P
Paul Bates
Researcher at University of Pennsylvania
Publications - 96
Citations - 10529
Paul Bates is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Virus & Ebola virus. The author has an hindex of 42, co-authored 87 publications receiving 7491 citations. Previous affiliations of Paul Bates include Michigan State University & University of California, San Francisco.
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Journal ArticleDOI
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
Graham Simmons,Dhaval N. Gosalia,Andrew J. Rennekamp,Jacqueline D. Reeves,Scott L. Diamond,Paul Bates +5 more
TL;DR: It is demonstrated here that the lysosomotropic-agent-mediated block to SARS-CoV infection is overcome by protease treatment of target-cell-associated virus, and the requirement for cathepsin L proteolysis identifies a previously uncharacterized class of inhibitor for SARS
Journal ArticleDOI
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
Graham Simmons,Jacqueline D. Reeves,Andrew J. Rennekamp,Sean M. Amberg,Andrew J. Piefer,Paul Bates +5 more
TL;DR: Conditions that result not only in the efficient expression of the SARS-CoV spike (S) protein on the surface of cells, but in its incorporation into lentiviral particles that can be used to transduce cells in an S glycoprotein-dependent manner are described.
Journal ArticleDOI
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
Rishi R. Goel,Mark M Painter,Sokratis A. Apostolidis,Divij Mathew,Wenzhao Meng,Aaron M. Rosenfeld,Kendall A. Lundgreen,Arnold Reynaldi,David S. Khoury,Ajinkya Pattekar,Sigrid Gouma,Leticia Kuri-Cervantes,Philip Hicks,Sarah Dysinger,Amanda Hicks,Harsh Sharma,Sarah Herring,Scott Korte,Amy E. Baxter,Derek A. Oldridge,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Moses Awofolaju,Nicole Tanenbaum,Elizabeth M Drapeau,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Maura McLaughlin,Justine C. Williams,Sharon Adamski,Oliva Kuthuru,Ian Frank,Michael R. Betts,Laura A. Vella,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Scott E. Hensley,Miles P. Davenport,Paul Bates,Eline T. Luning Prak,Allison R. Greenplate,E. John Wherry,S. Adamski,Z. Alam,M. M. Addison,K. T. Byrne,A. Chandra,H. C. Descamps,Nicholas Han,Y. Kaminskiy,S. C. Kammerman,Justin Kim,A. R. Greenplate,J. T. Hamilton,N. Markosyan,J. Han Noll,D. K. Omran,A. Pattekar,E. Perkey,E. M. Prager,D. Pueschl,A. Rennels,J. B. Shah,J. S. Shilan,N. Wilhausen,A. N. Vanderbeck +70 more
TL;DR: The durability of immune memory after SARS-CoV-2 mRNA vaccination was investigated in this article, where the majority of these cells cross-binding the Alpha, Beta, and Delta variants.
Journal ArticleDOI
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination.
Rishi R. Goel,Sokratis A. Apostolidis,Mark M Painter,Divij Mathew,Ajinkya Pattekar,Oliva Kuthuru,Sigrid Gouma,Philip Hicks,Wenzhao Meng,Aaron M. Rosenfeld,Sarah Dysinger,Kendall A. Lundgreen,Leticia Kuri-Cervantes,Sharon Adamski,Amanda Hicks,Scott Korte,Derek A. Oldridge,Amy E. Baxter,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Michael R. Betts,Eline T. Luning Prak,Paul Bates,Scott E. Hensley,Allison R. Greenplate,E. John Wherry +30 more
TL;DR: In this paper, the authors investigated antibody and antigen-specific memory B cells over time in 33 SARS-CoV-2 naive and 11 SARS CoV2 recovered subjects.
Journal ArticleDOI
Characterization of Ebola Virus Entry by Using Pseudotyped Viruses: Identification of Receptor-Deficient Cell Lines
Rouven J. Wool-Lewis,Paul Bates +1 more
TL;DR: The generation of high-titer MLV(Ebola) pseudotypes will be useful for the analysis of immune responses to Ebola virus infection, development of neutralizing antibodies, analysis of glycoprotein function, and isolation of the cellular receptor(s) for the Ebola virus.