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Eline T. Luning Prak
Researcher at University of Pennsylvania
Publications - 143
Citations - 8887
Eline T. Luning Prak is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 41, co-authored 123 publications receiving 5991 citations. Previous affiliations of Eline T. Luning Prak include Princeton University.
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Journal ArticleDOI
The ITP syndrome: pathogenic and clinical diversity
TL;DR: It is suggested that primary ITP is also best thought of as an autoimmune syndrome and better understanding of pathogenesis and tolerance checkpoint defects leading to autoantibody formation may facilitate patient-specific approaches to diagnosis and management.
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Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
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mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
Rishi R. Goel,Mark M Painter,Sokratis A. Apostolidis,Divij Mathew,Wenzhao Meng,Aaron M. Rosenfeld,Kendall A. Lundgreen,Arnold Reynaldi,David S. Khoury,Ajinkya Pattekar,Sigrid Gouma,Leticia Kuri-Cervantes,Philip Hicks,Sarah Dysinger,Amanda Hicks,Harsh Sharma,Sarah Herring,Scott Korte,Amy E. Baxter,Derek A. Oldridge,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Moses Awofolaju,Nicole Tanenbaum,Elizabeth M Drapeau,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Maura McLaughlin,Justine C. Williams,Sharon Adamski,Oliva Kuthuru,Ian Frank,Michael R. Betts,Laura A. Vella,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Scott E. Hensley,Miles P. Davenport,Paul Bates,Eline T. Luning Prak,Allison R. Greenplate,E. John Wherry,S. Adamski,Z. Alam,M. M. Addison,K. T. Byrne,A. Chandra,H. C. Descamps,Nicholas Han,Y. Kaminskiy,S. C. Kammerman,Justin Kim,A. R. Greenplate,J. T. Hamilton,N. Markosyan,J. Han Noll,D. K. Omran,A. Pattekar,E. Perkey,E. M. Prager,D. Pueschl,A. Rennels,J. B. Shah,J. S. Shilan,N. Wilhausen,A. N. Vanderbeck +70 more
TL;DR: The durability of immune memory after SARS-CoV-2 mRNA vaccination was investigated in this article, where the majority of these cells cross-binding the Alpha, Beta, and Delta variants.
Journal ArticleDOI
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination.
Rishi R. Goel,Sokratis A. Apostolidis,Mark M Painter,Divij Mathew,Ajinkya Pattekar,Oliva Kuthuru,Sigrid Gouma,Philip Hicks,Wenzhao Meng,Aaron M. Rosenfeld,Sarah Dysinger,Kendall A. Lundgreen,Leticia Kuri-Cervantes,Sharon Adamski,Amanda Hicks,Scott Korte,Derek A. Oldridge,Amy E. Baxter,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Michael R. Betts,Eline T. Luning Prak,Paul Bates,Scott E. Hensley,Allison R. Greenplate,E. John Wherry +30 more
TL;DR: In this paper, the authors investigated antibody and antigen-specific memory B cells over time in 33 SARS-CoV-2 naive and 11 SARS CoV2 recovered subjects.
Journal ArticleDOI
Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
TL;DR: The site-directed transgenic mouse model provides direct evidence for secondary rearrangement at VH-D-JH, which may play a role in tolerance by editing autoreactive receptors and may also serve to diversify the VH repertoire.