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Aaron M. Rosenfeld
Researcher at University of Pennsylvania
Publications - 40
Citations - 2770
Aaron M. Rosenfeld is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Immune system & Biology. The author has an hindex of 14, co-authored 31 publications receiving 1173 citations. Previous affiliations of Aaron M. Rosenfeld include Hospital of the University of Pennsylvania & Drexel University.
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Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Journal ArticleDOI
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
Rishi R. Goel,Mark M Painter,Sokratis A. Apostolidis,Divij Mathew,Wenzhao Meng,Aaron M. Rosenfeld,Kendall A. Lundgreen,Arnold Reynaldi,David S. Khoury,Ajinkya Pattekar,Sigrid Gouma,Leticia Kuri-Cervantes,Philip Hicks,Sarah Dysinger,Amanda Hicks,Harsh Sharma,Sarah Herring,Scott Korte,Amy E. Baxter,Derek A. Oldridge,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Moses Awofolaju,Nicole Tanenbaum,Elizabeth M Drapeau,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Maura McLaughlin,Justine C. Williams,Sharon Adamski,Oliva Kuthuru,Ian Frank,Michael R. Betts,Laura A. Vella,Alba Grifoni,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Scott E. Hensley,Miles P. Davenport,Paul Bates,Eline T. Luning Prak,Allison R. Greenplate,E. John Wherry,S. Adamski,Z. Alam,M. M. Addison,K. T. Byrne,A. Chandra,H. C. Descamps,Nicholas Han,Y. Kaminskiy,S. C. Kammerman,Justin Kim,A. R. Greenplate,J. T. Hamilton,N. Markosyan,J. Han Noll,D. K. Omran,A. Pattekar,E. Perkey,E. M. Prager,D. Pueschl,A. Rennels,J. B. Shah,J. S. Shilan,N. Wilhausen,A. N. Vanderbeck +70 more
TL;DR: The durability of immune memory after SARS-CoV-2 mRNA vaccination was investigated in this article, where the majority of these cells cross-binding the Alpha, Beta, and Delta variants.
Journal ArticleDOI
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination.
Rishi R. Goel,Sokratis A. Apostolidis,Mark M Painter,Divij Mathew,Ajinkya Pattekar,Oliva Kuthuru,Sigrid Gouma,Philip Hicks,Wenzhao Meng,Aaron M. Rosenfeld,Sarah Dysinger,Kendall A. Lundgreen,Leticia Kuri-Cervantes,Sharon Adamski,Amanda Hicks,Scott Korte,Derek A. Oldridge,Amy E. Baxter,Josephine R. Giles,Madison E. Weirick,Christopher M McAllister,Jeanette Dougherty,Sherea Long,Kurt D'Andrea,Jacob T. Hamilton,Michael R. Betts,Eline T. Luning Prak,Paul Bates,Scott E. Hensley,Allison R. Greenplate,E. John Wherry +30 more
TL;DR: In this paper, the authors investigated antibody and antigen-specific memory B cells over time in 33 SARS-CoV-2 naive and 11 SARS CoV2 recovered subjects.
Journal ArticleDOI
NBC: the Naïve Bayes Classification tool webserver for taxonomic classification of metagenomic reads
TL;DR: A webserver that implements the naïve Bayes classifier (NBC) to classify all metagenomic reads to their best taxonomic match is introduced and results indicate that NBC can assign next-generation sequencing reading to their taxonomic classification and can find significant populations of genera that other classifiers may miss.
Journal ArticleDOI
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Mohamad-Gabriel Alameh,István Tombácz,Emily Bettini,Katlyn Lederer,Chutamath Sittplangkoon,Joel R. Wilmore,Brian T. Gaudette,Ousamah Younoss Soliman,Matthew Pine,Philip Hicks,Tomaz B. Manzoni,James J. Knox,John L. Johnson,Dorottya Laczkó,Hiromi Muramatsu,Benjamin Davis,Wenzhao Meng,Aaron M. Rosenfeld,Shirin Strohmeier,Paulo J.C. Lin,Barbara L. Mui,Ying K. Tam,Katalin Karikó,Alain Jacquet,Florian Krammer,Paul Bates,Michael P. Cancro,Drew Weissman,Eline T. Luning Prak,David Allman,Michela Locci,Norbert Pardi +31 more
TL;DR: In this article, a lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanism of action of this vaccine platform is not well-characterized.