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Paul Bourgine
Researcher at Lund University
Publications - 102
Citations - 6924
Paul Bourgine is an academic researcher from Lund University. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 28, co-authored 99 publications receiving 6376 citations. Previous affiliations of Paul Bourgine include University Hospital of Basel & Université Paris-Saclay.
Papers
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From Molecules to Organisms: Towards Multiscale Integrated Models of Biological Systems
Christophe Lavelle,Hugues Berry,Guillaume Beslon,Francesco Giulio Ginelli,Jean-Louis Giavitto,Zoi Kapoula,André Le Bivic,Nadine Peyriéras,Ovidiu Radulescu,Adrien Six,Véronique Thomas-Vaslin,Paul Bourgine +11 more
TL;DR: The aim of this collective paper is to provide a starting point for further discussions and interactions within the community of complex systems biologists, and present four major challenges that should be tackled in the next years.
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Bounded rationality modeling
Bertrand Munier,Reinhard Selten,Denis Bouyssou,Paul Bourgine,Richard H. Day,Nigel Harvey,Denis Hilton,Mark J. Machina,Ph. Parker,John D. Sterman,Elke U. Weber,Birger Wernerfelt,Robin Wensley +12 more
TL;DR: In this article, the authors deal with bounded rationality as a way to describe behavior and focus on the question of how to build such boundedly rational models, and discuss the reasons why such models are needed and on the situations in which they can be regarded as more particularly useful.
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$3D+t$ Morphological Processing: Applications to Embryogenesis Image Analysis
Miguel Luengo-Oroz,David Pastor-Escuredo,Carlos Castro-Gonzalez,Emmanuel Faure,Thierry Savy,Benoit Lombardot,José L. Rubio-Guivernau,Louise Duloquin,Maria J. Ledesma-Carbayo,Paul Bourgine,Nadine Peyriéras,Andres Santos +11 more
TL;DR: The proposed processing paradigm produces spatio-temporal coherent results as it benefits from the intrinsic redundancy of the temporal dimension, and minimizes the needs for human intervention in semi-automatic algorithms.
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Engineered humanized bone organs maintain human hematopoiesis in vivo.
Kristin Fritsch,Sebastien Pigeot,Xiaomin Feng,Paul Bourgine,Paul Bourgine,Timm Schroeder,Ivan Martin,Markus G. Manz,Hitoshi Takizawa,Hitoshi Takizawa +9 more
TL;DR: It is reported that human ossicles in immunodeficient mice maintain human immature and mature hematopoiesis in vivo, and a higher percentage of human stem and progenitor cells are kept in quiescence in human Ossicles as compared with mouse BM.
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Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches
Andrés García-García,Thibaut Klein,Gordian Born,Morgane Hilpert,Arnaud Scherberich,Claudia Lengerke,Radek C. Skoda,Paul Bourgine,Ivan Martin +8 more
TL;DR: In this article, a 3D O-N was constructed for malignant CD34+ cells from acute myeloid leukemia (AML) and myeloproliferative neoplasm patients for up to three weeks.