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Paul E. Andrews

Researcher at Mayo Clinic

Publications -  106
Citations -  3834

Paul E. Andrews is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Nephrectomy & Prostatectomy. The author has an hindex of 34, co-authored 106 publications receiving 3588 citations. Previous affiliations of Paul E. Andrews include Boston Children's Hospital & University of Arkansas for Medical Sciences.

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Journal Article

Hormonal regulation of prostate-specific antigen messenger RNA in human prostatic adenocarcinoma cell line LNCaP

TL;DR: A specific oligonucleotide probe is developed which recognizes PSA but not the human glandular kallikrein, suggesting strongly that the androgensic effects on PSA mRNA in LNCaP cells may be via the function of the androgen receptor.
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Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein.

TL;DR: In situ hybridization and in vitro translation experiments demonstrated that the molecular size of the hGK-1 protein generated from this cDNA is similar to that of prostate-specific antigen (PSA), a protein which is produced exclusively in the prostate.
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Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP.

TL;DR: It is demonstrated that the PSA glycoprotein is upregulated by androgens and is affected by neither epidermal growth factor nor basic fibroblast growth factor, and the mutation of the receptor can affect the expression of this cellular gene by the steroids other than androgens.
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Original Articles: Kidney Cancer: Prospective Analysis of Multifocality in Renal Cell Carcinoma: Influence of Histological Pattern, Grade, Number, Size, Volume and Deoxyribonucleic Acid Ploidy

TL;DR: Information from preoperative and to some degree intraoperative tests (except histological pattern) cannot reliably predict multifocality, which roughly corresponds to the incidence of locally recurrent disease in published large institutional series.