This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.3322/caac.21660

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.

世界経済・社会統計 = World development indicators

Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of SARS-CoV-2 and SARS-CoV-1 under experimental conditions. The viability of the two virus...

https://www.nejm.org/doi/pdf/10.1056/NEJMc2004973?articleTools=true

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1.

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)61690-6.pdf

Closing the gap in a generation: health equity through action on the social determinants of health

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(15)60097-6.pdf

Panel: The nine volumes of Disease Control Priorities, 3rd edition Volume 1: Essential surgery

'It is this which is normal' A qualitative study on girl child marriage and health in conakry, Guinea.

A sustainable approach to universal health coverage - Authors' reply.

In reply to ‘“Universal” access for MDR-TB limited without the involvement of the private sector’ [Correspondence]

This chapter reviews the global distribution of HIV and AIDS and examines subepidemics that are illustrative of the unequal burden of HIV risk around the world. It is estimated that between 25 and 28 million people with HIV and AIDS are currently living in sub-Saharan Africa and between 3 and 4 million people are newly infected with HIV in this region every year. The chapter discusses several issues related to treatment access and examines several models and innovative programs that combine comprehensive HIV prevention and care with services aimed at addressing poverty and inequality. Social conditions, rather than ignorance about HIV and its modes of transmission, are the primary determinants of risk in many of the poorest parts of the world. The integration of HIV prevention and care will be a recurrent and unifying theme of global AIDS control efforts despite a great diversity in subepidemics.

Paul Farmer

Papers

Panel: The nine volumes of Disease Control Priorities, 3rd edition Volume 1: Essential surgery

'It is this which is normal' A qualitative study on girl child marriage and health in conakry, Guinea.

A sustainable approach to universal health coverage - Authors' reply.

In reply to ‘“Universal” access for MDR-TB limited without the involvement of the private sector’ [Correspondence]

11 – The Ever-changing Face of AIDS: Implications for Patient Care