P
Paul H. Lange
Researcher at University of Washington
Publications - 267
Citations - 17370
Paul H. Lange is an academic researcher from University of Washington. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 72, co-authored 267 publications receiving 16695 citations. Previous affiliations of Paul H. Lange include College of Health Sciences, Bahrain & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease: A Prospective Multicenter Clinical Trial
William J. Catalona,Alan W. Partin,Kevin M. Slawin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Jean B. deKernion,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Eric N.P. Subong,Robert E. Parson,Gail H. Gasior,Kathleen G. Loveland,Paula C. Southwick +15 more
TL;DR: Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer.
Journal ArticleDOI
Screening for Prostatic Carcinoma with Prostate Specific Antigen
Michael K. Brawer,Michael P. Chetner,Jeanette Beatie,David M. Buchner,Robert L. Vessella,Paul H. Lange +5 more
TL;DR: It is concluded that PSA represents an important adjunct to digital rectal examination for the early detection of prostatic carcinoma and the efficacy of this or any other early detection test to decrease prostate cancer mortality necessitates the results of prospectively randomized clinical trials.
Journal ArticleDOI
Substantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
Akash Kumar,Ilsa Coleman,Colm Morrissey,Xiaotun Zhang,Lawrence D. True,Roman Gulati,Ruth Etzioni,Hamid Bolouri,Bruce Montgomery,Thomas A. White,Jared M. Lucas,Lisha G. Brown,Ruth Dumpit,Navonil DeSarkar,Celestia S. Higano,Evan Y. Yu,Roger Coleman,Nikolaus Schultz,Min Fang,Min Fang,Paul H. Lange,Jay Shendure,Robert L. Vessella,Peter S. Nelson +23 more
TL;DR: Analysis of multiple tumors from men with disseminated prostate cancer indicates that evaluating a single metastasis provides a reasonable assessment of the major oncogenic driver alterations that are present in disseminated tumors within an individual, and thus may be useful for selecting treatments on the basis of predicted molecular vulnerabilities.
Journal ArticleDOI
The Value of Serum Prostate Specific Antigen Determinations Before and after Radical Prostatectomy
TL;DR: Prostatic acid phosphatase serum values after radical prostatectomy were not useful to predict persistent disease and may alter concepts about surgical results, and possibly shorten and sharpen clinical studies involving adjuvant therapy after radicalprostatectomy.
Journal ArticleDOI
Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease: A Prospective Multicenter Clinical Trial
William J. Catalona,Alan W. Partin,Kevin M. Slawin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Jean B. deKernion,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Eric N.P. Subong,Robert E. Parson,Gail H. Gasior,Kathleen G. Loveland,Paula C. Southwick +15 more
TL;DR: Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer.