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Paula C. Southwick
Researcher at Beckman Coulter
Publications - 33
Citations - 5477
Paula C. Southwick is an academic researcher from Beckman Coulter. The author has contributed to research in topics: Prostate cancer & Prostate-specific antigen. The author has an hindex of 24, co-authored 33 publications receiving 5330 citations. Previous affiliations of Paula C. Southwick include Washington University in St. Louis & San Diego State University.
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Journal ArticleDOI
Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men.
William J. Catalona,Jerome P. Richie,Frederick R. Ahmann,M'Liss A. Hudson,Peter T. Scardino,Robert C. Flanigan,Jean B. deKernion,Timothy L. Ratliff,Louis R. Kavoussi,Bruce L. Dalkin,W. Bedford Waters,Michael T. Macfarlane,Paula C. Southwick +12 more
TL;DR: In this paper, a prospective clinical trial at 6 university centers of 6,630 male volunteers 50 years old or older who underwent PSA determination (Hybritech Tandom-E or Tandem-R assays) and digital rectal examination was conducted.
Journal ArticleDOI
Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease: A Prospective Multicenter Clinical Trial
William J. Catalona,Alan W. Partin,Kevin M. Slawin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Jean B. deKernion,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Eric N.P. Subong,Robert E. Parson,Gail H. Gasior,Kathleen G. Loveland,Paula C. Southwick +15 more
TL;DR: Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer.
Journal ArticleDOI
Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease: A Prospective Multicenter Clinical Trial
William J. Catalona,Alan W. Partin,Kevin M. Slawin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Jean B. deKernion,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Eric N.P. Subong,Robert E. Parson,Gail H. Gasior,Kathleen G. Loveland,Paula C. Southwick +15 more
TL;DR: Use of the percentage of free PSA can reduce unnecessary biopsies in patients undergoing evaluation for prostate cancer, with a minimal loss in sensitivity in detecting cancer.
Journal ArticleDOI
Comparison of percent free PSA, PSA density, and age-specific PSA cutoffs for prostate cancer detection and staging.
William J. Catalona,Paula C. Southwick,Kevin M. Slawin,Alan W. Partin,Michael K. Brawer,Robert C. Flanigan,Anup Patel,Jerome P. Richie,Patrick C. Walsh,Peter T. Scardino,Paul H. Lange,Gail H. Gasior,Kathleen G. Loveland,Kurtis R. Bray +13 more
TL;DR: It is demonstrated that cancer detection (sensitivity) is significantly higher with fPSA than with age-specific PSA reference ranges, and that %fPSA may be used in place of PSAD for biopsy decisions and in algorithms for prediction of less aggressive tumors since the determination of %f PSA does not require ultrasound.
Journal ArticleDOI
Selection of Optimal Prostate Specific Antigen Cutoffs for Early Detection of Prostate Cancer: Receiver Operating Characteristic Curves
William J. Catalona,M'liss A. Hudson,Peter T. Scardino,Jerome P. Richie,Frederick R. Ahmann,Robert C. Flanigan,Jean B. deKernion,Timothy L. Ratliff,Louis R. Kavoussi,Bruce L. Dalkin,W.B. Waters,Michael T. Macfarlane,Paula C. Southwick +12 more
TL;DR: A prospective clinical trial of prostate cancer screening was conducted at 6 university centers including 6,630 men 50 years old or older who underwent a serum prostate specific antigen (PSA) determination and digital rectal examination, which concluded that a serum PSA concentration of 4.0 ng./ml should be used as a general guideline for biopsy in all age groups.