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Paul J. Grippo
Researcher at University of Illinois at Chicago
Publications - 97
Citations - 4123
Paul J. Grippo is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Pancreatic cancer & Pancreas. The author has an hindex of 31, co-authored 86 publications receiving 3415 citations. Previous affiliations of Paul J. Grippo include Northwestern University.
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Journal ArticleDOI
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Carmen Guerra,Alberto J. Schuhmacher,Marta Cañamero,Paul J. Grippo,Lena Verdaguer,Lucía Pérez-Gallego,Pierre Dubus,Eric P. Sandgren,Mariano Barbacid +8 more
TL;DR: It is reported that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acINs or their precursors into ductal-like cells.
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TGF-β: Duality of Function Between Tumor Prevention and Carcinogenesis
Daniel R. Principe,Jennifer A. Doll,Jessica Bauer,Barbara Jung,Hidayatullah G. Munshi,Laurent Bartholin,Boris Pasche,Chung Lee,Chung Lee,Paul J. Grippo +9 more
TL;DR: Understanding the mechanisms of TGF-β dysregulation will likely reveal novel points of convergence between T GF-β and other pathways that can be specifically targeted for therapy, particularly in relation to transforming growth factor beta.
Journal Article
The Mutant K-ras Oncogene Causes Pancreatic Periductal Lymphocytic Infiltration and Gastric Mucous Neck Cell Hyperplasia in Transgenic Mice
Felix H. Brembeck,Franz S. Schreiber,Therese B. Deramaudt,Linden E. Craig,Ben Rhoades,Gary P. Swain,Paul J. Grippo,Doris A. Stoffers,Debra G. Silberg,Anil K. Rustgi +9 more
TL;DR: How mutant K-ras signaling modulates important molecular events in the initiating events of pancreatic and gastric carcinogenesis is defined.
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Three dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
Surabhi Dangi-Garimella,Seth B. Krantz,Morgan R. Barron,Mario A. Shields,Michael J. Heiferman,Paul J. Grippo,David J. Bentrem,Hidayatullah G. Munshi +7 more
TL;DR: It is shown that the type I collagen allows PDAC cells to override checkpoint arrest induced by gemcitabine, and it is suggested that targeting MT1-MMP could be a novel approach to sensitize pancreatic tumors to gem citabine.
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TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis
Daniel R. Principe,Brian DeCant,Emman Mascariñas,Elizabeth A. Wayne,Elizabeth A. Wayne,Andrew M. Diaz,Naomi Akagi,Rosa F. Hwang,Boris Pasche,David W. Dawson,Deyu Fang,David J. Bentrem,Hidayatullah G. Munshi,Barbara Jung,Paul J. Grippo +14 more
TL;DR: It is suggested that, despite opposing the proliferation of some epithelial cells, TGFβ may promote pancreatic cancer development by affecting stromal and hematopoietic cell function, and the use of TGFBR inhibition to target components of the tumor microenvironment warrants consideration as a potential therapy.