L
Laura K. Mackay
Researcher at University of Melbourne
Publications - 84
Citations - 8228
Laura K. Mackay is an academic researcher from University of Melbourne. The author has contributed to research in topics: Immune system & CD8. The author has an hindex of 29, co-authored 64 publications receiving 6161 citations. Previous affiliations of Laura K. Mackay include Australian Research Council & University of Birmingham.
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Journal ArticleDOI
The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.
Laura K. Mackay,Azad Rahimpour,Joel Z. Ma,Nicholas Collins,Angus T. Stock,Ming-Li Hafon,Javier Vega-Ramos,Pilar Lauzurica,Scott N. Mueller,Tijana Stefanovic,David C. Tscharke,William R. Heath,Michael Inouye,Francis R. Carbone,Thomas Gebhardt +14 more
TL;DR: It is found that CD103+CD8+ TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1.
Journal ArticleDOI
Tissue-resident memory T cells: local specialists in immune defence
TL;DR: This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
Journal ArticleDOI
Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes.
Laura K. Mackay,Laura K. Mackay,Martina Minnich,Natasja A. M. Kragten,Yang Liao,Yang Liao,Benjamin Nota,Cyril Seillet,Cyril Seillet,Ali Zaid,Kevin Man,Kevin Man,Simon Preston,Simon Preston,David Freestone,Asolina Braun,Erica Wynne-Jones,Felix M. Behr,Regina Stark,Daniel G. Pellicci,Daniel G. Pellicci,Dale I. Godfrey,Dale I. Godfrey,Gabrielle T. Belz,Gabrielle T. Belz,Marc Pellegrini,Marc Pellegrini,Thomas Gebhardt,Meinrad Busslinger,Wei Shi,Wei Shi,Francis R. Carbone,René A. W. van Lier,Axel Kallies,Axel Kallies,Klaas P. J. M. van Gisbergen +35 more
TL;DR: In this paper, the authors identify Hobit and Blimp1 as central regulators of a universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations, including NKT cells and liver-resident NK cells.
Journal ArticleDOI
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
Peter Savas,Balaji Virassamy,Chengzhong Ye,Agus Salim,Agus Salim,Christopher P. Mintoff,Franco Caramia,Roberto Salgado,David J Byrne,Zhi Ling Teo,Zhi Ling Teo,Sathana Dushyanthen,Ann Byrne,Lironne Wein,Stephen J Luen,Catherine Poliness,Sophie Nightingale,Anita S Skandarajah,Anita S Skandarajah,David E. Gyorki,Chantel M Thornton,Paul A. Beavis,Paul A. Beavis,Stephen B. Fox,Phillip K. Darcy,Phillip K. Darcy,Terence P. Speed,Terence P. Speed,Laura K. Mackay,Paul J Neeson,Paul J Neeson,Sherene Loi,Sherene Loi +32 more
TL;DR: Detailed, high-dimensional characterization of T cells in breast cancer reveals activated TRM population and a gene signature associated with improved prognosis and suggest that CD8+ TRM cells contribute to BC immunosurveillance and are the key targets of modulation by immune checkpoint inhibition.
Journal ArticleDOI
Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation
Laura K. Mackay,Angus T. Stock,Joel Z. Ma,Claerwen M. Jones,Stephen J. Kent,Scott N. Mueller,William R. Heath,Francis R. Carbone,Thomas Gebhardt +8 more
TL;DR: It is demonstrated that long-lived intraepithelial CD103+CD8+ TRM cells can be generated and survive in the absence of in situ antigen recognition and provide a powerful means of achieving immune protection against peripheral infection.