Showing papers by "Paul J. Orchard published in 2005"
TL;DR: It is suggested that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT.
1,573 citations
TL;DR: This study is the first report demonstrating that the SB transposon system can mediate stable gene transfer in human primary PBLs, which may be advantageous for T-cell-based gene therapies.
102 citations
TL;DR: It is concluded that OP patients with high levels of circulating CD34(+) are candidates for peripheral blood autologous harvest by limited exchange transfusion, and are then available for reinfusion should graft failure be observed in patients for whom retransplantation is impractical.
35 citations
TL;DR: AHSCT remains promising, especially for patients with sensitive relapse and lower IPI scores, and prolonged survival is further tempered by a significant risk of post-transplantation second malignancies, including myelodysplastic syndrome/acute myeloid leukemia and solid tumors.
21 citations
TL;DR: An overview of the Minnesota Molecular and Cellular Therapeutics (MMCT) Facility is provided, detailing the approach to the manufacture of novel therapeutics and highlighting current and future activities.
18 citations
TL;DR: Central pontine myelinolysis following bone marrow transplantation complicated by severe hepatic veno-occlusive disease is described.
Abstract: Central pontine myelinolysis following bone marrow transplantation complicated by severe hepatic veno-occlusive disease
6 citations
TL;DR: It is demonstrated that prolonged remissions can be obtained with either auto or alloHCT, especially for high risk patients in CR, and predicted of superior PFS: fewer chemotherapy regimens prior to transplantation and CR at time of transplant.
2 citations