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Paul J. Orchard
Researcher at University of Minnesota
Publications - 259
Citations - 14759
Paul J. Orchard is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 48, co-authored 229 publications receiving 12985 citations. Previous affiliations of Paul J. Orchard include University of Pennsylvania.
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Journal ArticleDOI
Graft-versus-leukemia is sufficient to induce remission in juvenile myelomonocytic leukemia.
TL;DR: A patient with JMML who relapsed early after an unrelated donor transplant, and following withdrawal of immunosuppression developed graft-versus-host disease (GVHD), which strongly suggest that GVL has a role in the control of JMML.
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Changes in the incidence, patterns and outcomes of graft failure following hematopoietic stem cell transplantation for Hurler syndrome
Su Han Lum,Weston P. Miller,Simon Jones,Kay Poulton,W Ogden,Helena Lee,A. Logan,Denise Bonney,Troy C. Lund,Paul J. Orchard,Rob Wynn +10 more
TL;DR: The pattern of graft failure has changed from autologous reconstitution, likely secondary to inadequate myelosuppression in the historical era, to aplasia in the current era, likely due to imperfect immunosuppressive.
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Pericardial effusion after pediatric hematopoietic cell transplant
Osamah Aldoss,Daniel H. Gruenstein,John L. Bass,Julia Steinberger,Yan Zhang,Todd E. DeFor,Jakub Tolar,Michael R. Verneris,Paul J. Orchard +8 more
TL;DR: PE is a common and significant complication of pediatric allo‐HCT, and patients with non‐malignant diseases were significantly less likely to die after development of PE than patients with standard and high‐risk diseases.
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Haemopoietic cell transplantation in children with juvenile myelomonocytic leukaemia
TL;DR: Six of seven patients with juvenile myelomonocytic leukaemia underwent allogeneic haemopoietic cell transplantation (HCT) using related or unrelated donor bone marrow or umbilical cord blood with one achieving a return to full donor chimaerism after cyclosporin A (CSA) withdrawal.
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Second allogeneic hematopoietic cell transplantation for graft failure: Poor outcomes for neutropenic graft failure
Troy C. Lund,Jessica Liegel,Nelli Bejanyan,Paul J. Orchard,Qing Cao,Jakub Tolar,Claudio G. Brunstein,John E. Wagner,Michael R. Verneris,Daniel J. Weisdorf +9 more
TL;DR: In this article, the authors describe the outcomes of 95 patients treated with a second HCT for GF at the University of Minnesota; 62 with neutropenia (NGF) and 33 with NNGF.