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Paul J. Orchard
Researcher at University of Minnesota
Publications - 259
Citations - 14759
Paul J. Orchard is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 48, co-authored 229 publications receiving 12985 citations. Previous affiliations of Paul J. Orchard include University of Pennsylvania.
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Journal ArticleDOI
Hematopoietic stem cell transplantation for infantile osteopetrosis.
Paul J. Orchard,Anders Fasth,Jennifer Le Rademacher,Jennifer Le Rademacher,Wensheng He,Jaap Jan Boelens,Edwin M. Horwitz,Amal Al-Seraihy,Mouhab Ayas,Carmem Bonfim,Farid Boulad,Troy C. Lund,David Buchbinder,Neena Kapoor,Tracey A. O'Brien,Miguel Pérez,Paul Veys,Mary Eapen +17 more
TL;DR: Though allogeneic transplantation results in long-term survival with acceptable social function, strategies to lower graft failure and hepatic and pulmonary toxicity are urgently needed.
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Long-term metabolic, endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease
Jakub Tolar,Anna Petryk,Khalid Khan,Kendra Bjoraker,Jose Jessurun,Michelle M Dolan,Teresa Kivisto,Lawrence Charnas,Elsa Shapiro,Paul J. Orchard +9 more
TL;DR: It is concluded that Wolman disease can be successfully treated with HCT, and that hepatic and cognitive function can be preserved with early diagnosis and timely referral to a transplant center.
Journal ArticleDOI
Hematopoietic cell therapy for metabolic disease.
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Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
Jakub Tolar,In-Hyun Park,Lily Xia,Christopher J. Lees,Brandon Peacock,Beau R. Webber,Ron T. McElmurry,Cindy R. Eide,Paul J. Orchard,Michael Kyba,Mark J. Osborn,Troy C. Lund,John E. Wagner,George Q. Daley,Bruce R. Blazar +14 more
TL;DR: In this article, induced pluripotent stem cells from 2 patients with MPS IH (MPS-iPS cells) were used to generate autologous hematopoietic grafts without immunologic complications of allogeneic transplantation.
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Analysis of Glycosaminoglycans in Cerebrospinal Fluid from Patients with Mucopolysaccharidoses by Isotope-Dilution Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry
Haoyue Zhang,Sarah P. Young,Christiane Auray-Blais,Paul J. Orchard,Jakub Tolar,David S. Millington +5 more
TL;DR: A method based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) has potential value in monitoring patients with mucopolysaccharidoses receiving treatment targeted to the brain.