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Paul J. Orchard
Researcher at University of Minnesota
Publications - 259
Citations - 14759
Paul J. Orchard is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 48, co-authored 229 publications receiving 12985 citations. Previous affiliations of Paul J. Orchard include University of Pennsylvania.
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Journal ArticleDOI
Multi-Institutional Assessments of Transplantation for Metabolic Disorders
TL;DR: The availability of enzyme replacement therapy (ERT) has provided the opportunity to explore combination therapy in disorders such as Hurler syndrome, whereas in other diseases, such as MaroteauxLamy syndrome, ERT has essentially replaced transplantation as standard therapy.
Journal Article
Gender-related dimorphism in aortic insufficiency in murine mucopolysaccharidosis type I.
Jakub Tolar,Elizabeth A. Braunlin,Megan J. Riddle,Brandon Peacock,Ron T. McElmurry,Paul J. Orchard,Bruce R. Blazar +6 more
TL;DR: Gender-related dimorphism occurs in cardiac valvular disease in MPSI mice and the evaluation of findings in relation to gender is important in the experimental treatment of murine models of disease, so that gender-related variations in genetic penetrance are not mistaken for disease correction.
Journal Article
Retroviral-mediated transfer of the murine interleukin-3 gene engineered for intracellular retention results in a myeloproliferative syndrome but is associated with circulating interleukin-3 levels
Paul J. Orchard,Detrick Ra,K. B. Gorden,Dunbar Ce,Daniel A. Vallera,Patricia A. Taylor,R S McIvor,Bruce R. Blazar +7 more
TL;DR: From these experiments, it seems unlikely that exclusively intracellular mechanisms are a major contributor to the development of the myeloproliferative syndrome observed in animals, including mice receiving marrow transduced with constructs containing the IL-3 gene modified for intrACEllular retention.
Journal ArticleDOI
Outcome After Cord Blood Transplantation Using Busulfan Pharmacokinetics-Targeted Myeloablative Conditioning for Hurler Syndrome
TL;DR: Survival after CBT for HS has improved but better strategies are needed to improve graft outcome, and washed CB unit and HLA ≤ 6/10 were associated with significantly lower ES.
Journal ArticleDOI
Biomarkers for prediction of skeletal disease progression in mucopolysaccharidosis type I.
Troy C. Lund,Terence M. Doherty,Julie B. Eisengart,Rebecca Freese,Kyle Rudser,Ellen B. Fung,Bradley S. Miller,Klane K. White,Paul J. Orchard,Chester B. Whitley,Lynda E. Polgreen +10 more
TL;DR: The primary objective of this study was to identify surrogate biomarkers of future change in orthopedic disease, and to identify surrogates of response to novel therapies and accurate predictors of response.