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Paul J. Orchard
Researcher at University of Minnesota
Publications - 259
Citations - 14759
Paul J. Orchard is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 48, co-authored 229 publications receiving 12985 citations. Previous affiliations of Paul J. Orchard include University of Pennsylvania.
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First Documentation of Cell-to-Cell Peroxisome Transfer in Hematopoietic Stem and Progenitor Cells: A Method to "Relieve Stress"?
TL;DR: In this article , peroxisome transfer from stroma to HSPC showed a transfer rate of up to 0.5 %, which could be achieved only when cell-to-cell contact took place; the use of transwells inhibited transfer.
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Conditioning Intensity, Modality, and Niche Clearance, Not Cell Dose, Determine Myeloid CNS Engraftment after Transplant
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A case series of adrenoleukodystrophy in children conceived through in vitro fertilization with an egg donor
Crystal Whai-Ku Chang,Ashish Gupta,Paul J. Orchard,David Nascene,J. Kierstein,Rebecca Tryon,Troy C. Lund +6 more
TL;DR: In this paper , the authors report three cases of adrenoleukodystrophy (ALD) transmission in children conceived by in vitro fertilization (IVF) and egg donation, and they highlight the potential need to implement more comprehensive genetic screening of gamete donors to prevent the transfer of rare but severe genetic diseases through IVF.
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Developmental delay can precede neurologic regression in metachromatic leukodystrophy
Laura Adang,Samuel Groeschel,C. Grzyb,Florian Eichler,Jamie L. Fraser,Lisa Emrick,Keith Van Haren,Stephanie Keller,Michele D. Poe,John A. Bernat,Joshua L. Bonkowsky,Geneviève Bernard,Chloe A Stutterd,Paul J. Orchard,Ashish Gupta,Merete Ljungberg,Sabine Grønborg,Francesca Fumagalli,Saskia Elgun,Christiane Kehrer,Justine Shults,Adeline Vanderver,Maria L. Escolar +22 more
TL;DR: In this paper , a simplified desensitization protocol (SWORD) was successfully achieved, allowing substitute enzyme replacement therapy (ERT) to be pursued, resulting eventually in clinical improvement, considering the lack of therapeutic alternatives and the proved benefit of ERT.
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Adrenoleukodystrophy Protein (ALDP) Antibody Formation and Graft Loss in Gene Therapy for Adrenoleukodystrophy
TL;DR: A nine-year boy with adrenoleukodystrophy (ALD) due to an ABCD1 whole gene deletion was diagnosed with the active cerebral form of disease characterized by demyelination and gadolinium enhancement on brain MRI as mentioned in this paper .