Showing papers in "Blood in 1977"

TL;DR: In this paper, clinical and hematologic studies of 16 adult patients whose leukemic cells had T-cell markers are reported from Japan, where the incidence of various lymphoproliferative diseases differs considerably from that in Western countries.

TL;DR: One hundred patients, 54 with acute myelogenous leukemia (AML) and 46 with acute lymphoblastic leukemia (ALL), considered to be in the end stages of their disease, after combination chemotherapy were treated by marrow transplantation as discussed by the authors.

TL;DR: In this article, a human lung cancer (OTUK-tumor) was transplanted serially to nude mice, which invariably developed a marked neutrophilia, and a three to fourfold increase of colony-forming units in culture was observed in the femurs of these nude mice.

TL;DR: Medium conditioned by human placental tissue was found to stimulate granulocytic and monocytic colony formation by human marrow cells in semisolid agar cultures and the active factor was not dependent on the presence of adherent marrow cells with endogenous colony-stimulating activity.

TL;DR: Evidence is presented for the existence of an intracellular pool of low molecular weight iron compounds which acts as an intermediate between extracellular iron and a wide variety of intrace cellular processes.

TL;DR: Differences of platelet volume and structure between light and heavy platelets suggested that aging may be a determinant of Platelet heterogeneity.

TL;DR: From the data obtained it would appear that male donors, while depleting their iron stores, were able to donate 2-3 U/yr without an appreciable incidence of iron deficiency, and more frequent donations were associated with a high incidence ofIron deficiency and donor dropout.

TL;DR: The previously reported enhancing effect of human leukocyte conditioned medium on burst formation seen in cultures of human nonadherent cells was found to be due largely to an effect on the formation of the largest, late appearing type of burst.

TL;DR: Two patients with thrombotic thromBocytopenic purpura (TTP) have recovered completely after intensive plasmapheresis, and the possibility that this agent may be an immune complex is discussed.

TL;DR: Results and the ability of the elastase-like protease to destroy isolated clotting factors suggested that in certain types of coagulation factor deficiencies direct proteolysis rather than consumption of clotting Factors due to disseminated intravascular coagulations may be operational.

TL;DR: Chromosomal analyses of myeloid cells were performed on ten patients who had acute nonlymphocytic leukemia (ANLL) following treatment for malignant lymphoma, finding the chromosomal pattern of hypodiploid cell lines found in ANLL de novo was similar to that occurring in treated lymphoma.

TL;DR: It is suggested that propranolol, like local anesthetics, decreased platelet responsiveness by a direct action on the platelet membrane, possibly by interfering with calcium availability.

TL;DR: The hypothesis that directed movement and phagocytosis by PMN are attenuated by autooxidative damage to the cell membrane by endogenously derived H2O2 is supported and that the administration in vivo of vitamin E may prevent this damage by scavenging H2 O2.

TL;DR: The tissue-factor (thromboplastic) activity of cultured human endothelial cells and fibroblasts is low at time of transfer into fresh medium but increases 3–10 fold, and the kinetics of expression of smooth muscle cell tissue factor are markedly different from other cell types.

TL;DR: The results suggest that the superoxide-forming enzyme from human neutrophils is a FAD-requiring enzyme, and particle extracted with detergent prior to assay show little activity if FAD is omitted from the assay mixture.

TL;DR: There was a progressive increase in jugular vein bleeding time with both increasing APTT values and heparin levels in both groups of animals, and in these cryoprecipitate-treated animals, marked inhibition of fibrinogen accretion occurred at a similar level ofHeparin activity but at a significantly lower APTT than in normal animals.

TL;DR: BACOP resulted in a higher CR rate and longer survival than a previous three-drug program (COP), especially in patients with diffuse histology.

TL;DR: Combined chemotherapy with these agents is effective in increasing the CR rate and survival in patients with diffuse histiocytic lymphoma, and further observation will be needed to assess the effect of this combination on survival.

TL;DR: Overall survival was best in the intermittent CLB arm, there was no significant difference in survival time between the three treatment schedules, and Toxicity was minimal in all three regimens.

TL;DR: It is demonstrated that a single episode of fever in man produced rapid and prolonged changes in serum iron and ferritin concentrations.

TL;DR: Examination of the proliferative state of the erythropoietic precursors using high specific activity tritium-labeled thymidine revealed that almost none of the cells in normal men or patients with hemoglobinopathies were in the DNA synthetic phase.

TL;DR: It was found that Hageman factor fragments promoted rapid proteolysis of one-chain factor VII to a more active two-chain form, indicating that initiation of coagulation by the intrinsic pathway also primes the extrinsic pathway.

TL;DR: Data showed that the direct measurement of platelet associated antibody is a useful technique in the diagnosis and follow-up of patients with chronic ITP, and suggested that this method may be useful in differentiating acute and chronic childhood ITP.

TL;DR: The addition of combination chemotherapy to total nodal irradiation was associated with improved survival of patients in stage II, but not of those in stage III1, and the addition of combined chemotherapy tototal nodal radiotherapy with or without subsequent combination chemotherapy was not associated with better survival.

TL;DR: Data indicate that eosinophils possess a similar, although in some ways more potent, oxidative burst than neutrophils and are consistent with a role for NADPH oxidase in the initiation of that burst.

TL;DR: It was concluded that lithium promoted enhanced granulocyte production in vitro by stimulating the synthesis of CSA.

TL;DR: High-dose methotrexate with folinic acid (MTX/FA) was evaluated in patients with advanced non-Hodgkin lymphoma with unfavorable diffuse histology, with one patient remaining in remission 14�’ mo after treatment, with untoward reactions independent of the dose of MTX.

TL;DR: Hmatologic criteria for the diagnosis of blast crisis are presented and the importance of extramedullary leukemia in heralding the onset of blastrisis is emphasized.

TL;DR: It is found that in 5 recipients with antibodies prior to transplantation to antigens of the ABH system present on the cells of their donors, plasma exchange and antibody absorption in vivo were effective in permitting engraftment of ABO-incompatible bone marrow.