P
Paul M. Ballieu
Researcher at Huntsman Cancer Institute
Publications - 1
Citations - 365
Paul M. Ballieu is an academic researcher from Huntsman Cancer Institute. The author has contributed to research in topics: Aurora inhibitor & Tumor progression. The author has an hindex of 1, co-authored 1 publications receiving 233 citations.
Papers
More filters
Journal ArticleDOI
MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition
Gurkan Mollaoglu,Matthew R. Guthrie,Stefanie Böhm,Johannes Brägelmann,Ismail Can,Paul M. Ballieu,Annika Marx,Julie George,Christine Heinen,Milind D. Chalishazar,Haixia Cheng,Abbie S. Ireland,Kendall E. Denning,Anandaroop Mukhopadhyay,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Timothy L. Mosbruger,Jun Wang,Jessica L. Kohan,Mohamed E. Salama,Benjamin L. Witt,Martin Peifer,Roman K. Thomas,Roman K. Thomas,Jason Gertz,Jane E. Johnson,Adi F. Gazdar,Robert J. Wechsler-Reya,Martin L. Sos,Trudy G. Oliver +29 more
TL;DR: It is shown that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.