J
Johannes Brägelmann
Researcher at University of Cologne
Publications - 52
Citations - 2738
Johannes Brägelmann is an academic researcher from University of Cologne. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 20, co-authored 40 publications receiving 1994 citations. Previous affiliations of Johannes Brägelmann include University of Bonn & Heidelberg University.
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Journal ArticleDOI
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas
Tanguy Y. Seiwert,Zhixiang Zuo,Michaela K. Keck,Arun Khattri,Chandra Sekhar Pedamallu,Thomas Stricker,Christopher D. Brown,Trevor J. Pugh,Trevor J. Pugh,Petar Stojanov,Juok Cho,Michael S. Lawrence,Gad Getz,Johannes Brägelmann,Rebecca DeBoer,Ralph R. Weichselbaum,Alexander Langerman,Louis G. Portugal,Elizabeth A. Blair,Kerstin M. Stenson,Mark W. Lingen,Ezra E.W. Cohen,Everett E. Vokes,Kevin P. White,Peter S. Hammerman,Peter S. Hammerman +25 more
TL;DR: The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly, including targetable genes, includingtargetable genomic alterations in FGFR1, DDR2, EGFR, FGFR2/3, EPHA2, and PIK3CA.
Journal ArticleDOI
MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition
Gurkan Mollaoglu,Matthew R. Guthrie,Stefanie Böhm,Johannes Brägelmann,Ismail Can,Paul M. Ballieu,Annika Marx,Julie George,Christine Heinen,Milind D. Chalishazar,Haixia Cheng,Abbie S. Ireland,Kendall E. Denning,Anandaroop Mukhopadhyay,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Timothy L. Mosbruger,Jun Wang,Jessica L. Kohan,Mohamed E. Salama,Benjamin L. Witt,Martin Peifer,Roman K. Thomas,Roman K. Thomas,Jason Gertz,Jane E. Johnson,Adi F. Gazdar,Robert J. Wechsler-Reya,Martin L. Sos,Trudy G. Oliver +29 more
TL;DR: It is shown that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.
Journal ArticleDOI
Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes
Michaela K. Keck,Michaela K. Keck,Zhixiang Zuo,Arun Khattri,Thomas Stricker,Christopher D. Brown,Matin Imanguli,Damian Rieke,Katharina Endhardt,Petra Fang,Johannes Brägelmann,Rebecca DeBoer,Mohamed El-Dinali,Serdal Aktolga,Zhengdeng Lei,Patrick Tan,Patrick Tan,Steve Rozen,Ravi Salgia,Ralph R. Weichselbaum,Mark W. Lingen,Michael D. Story,K. Kian Ang,Ezra E.W. Cohen,Kevin P. White,Everett E. Vokes,Tanguy Y. Seiwert +26 more
TL;DR: Five subtypes of head and neck squamous cell carcinomas are identified, including two biologically distinct HPV subtypes, which provide a comprehensive overview of HPV+ as well as HPV− HNSCC biology with significant translational implications for biomarker development and personalized care for patients.
Journal ArticleDOI
K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways.
Matthias Scheffler,Michaela Angelika Ihle,Rebecca Hein,Sabine Merkelbach-Bruse,Andreas H. Scheel,Janna Siemanowski,Johannes Brägelmann,Anna Kron,Nima Abedpour,Frank Ueckeroth,Merle Schüller,Sophia Koleczko,Sebastian Michels,Jana Fassunke,Helen Pasternack,Carina Heydt,Monika Serke,Rieke Fischer,Wolfgang Schulte,Ulrich Gerigk,Lucia Nogova,Yon-Dschun Ko,Diana S.Y. Abdulla,Richard F. Riedel,Karl-Otto Kambartel,Joachim Lorenz,Imke Sauerland,Winfried Randerath,Britta Kaminsky,Lars Hagmeyer,Christian Grohé,Anna Eisert,Rieke Frank,Leonie Gogl,Carsten Schaepers,Alessandra Holzem,Martin Hellmich,Roman K. Thomas,Martin Peifer,Martin L. Sos,Reinhard Büttner,Jürgen Wolf +41 more
TL;DR: KRAS‐mutated NSCLC represents a genetically heterogeneous subgroup with a high frequency of co‐occurring mutations in cancer‐associated pathways, partly associated with distinct KRAS mutation subtypes.
Journal ArticleDOI
Web-TCGA: an online platform for integrated analysis of molecular cancer data sets
TL;DR: Web-TCGA as mentioned in this paper is a web-based, freely accessible online tool for integrated analysis of molecular cancer data sets provided by the Cancer Genome Atlas (TCGA), allowing users to generate global molecular profiles across different cancer entities simultaneously.