J
Jeffery M. Vahrenkamp
Researcher at Huntsman Cancer Institute
Publications - 14
Citations - 766
Jeffery M. Vahrenkamp is an academic researcher from Huntsman Cancer Institute. The author has contributed to research in topics: Estrogen receptor & Biology. The author has an hindex of 6, co-authored 9 publications receiving 408 citations. Previous affiliations of Jeffery M. Vahrenkamp include University of Utah.
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Journal ArticleDOI
MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition
Gurkan Mollaoglu,Matthew R. Guthrie,Stefanie Böhm,Johannes Brägelmann,Ismail Can,Paul M. Ballieu,Annika Marx,Julie George,Christine Heinen,Milind D. Chalishazar,Haixia Cheng,Abbie S. Ireland,Kendall E. Denning,Anandaroop Mukhopadhyay,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Timothy L. Mosbruger,Jun Wang,Jessica L. Kohan,Mohamed E. Salama,Benjamin L. Witt,Martin Peifer,Roman K. Thomas,Roman K. Thomas,Jason Gertz,Jane E. Johnson,Adi F. Gazdar,Robert J. Wechsler-Reya,Martin L. Sos,Trudy G. Oliver +29 more
TL;DR: It is shown that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.
Journal ArticleDOI
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Gurkan Mollaoglu,Alex Jones,Sarah J. Wait,Anandaroop Mukhopadhyay,Sangmin Jeong,Rahul Arya,Soledad A. Camolotto,Timothy L. Mosbruger,Chris Stubben,Christopher J. Conley,Arjun Bhutkar,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Melissa H. Cessna,Thomas E. Lane,Benjamin L. Witt,Mohamed E. Salama,Jason Gertz,Kevin B. Jones,Eric L. Snyder,Trudy G. Oliver +20 more
TL;DR: Mouse models of lung cancer recapitulate humanNSCLC immune microenvironment and define the relationship between lineage‐defining transcription factors and squamous NSCLC and adenocarcinoma, revealing that this interplay also determines neutrophil recruitment.
Journal ArticleDOI
MYC-driven small cell lung cancer is metabolically distinct and vulnerable to arginine depletion
Milind D. Chalishazar,Sarah J. Wait,Fang Huang,Fang Huang,Abbie S. Ireland,Anandaroop Mukhopadhyay,Younjee Lee,Sophia S. Schuman,Matthew R. Guthrie,Kristofer C. Berrett,Jeffery M. Vahrenkamp,Zeping Hu,Zeping Hu,Marek Kudla,Katarzyna Modzelewska,Guoying Wang,Nicholas T. Ingolia,Jason Gertz,David H. Lum,Sabina Cosulich,John S. Bomalaski,Ralph J. DeBerardinis,Trudy G. Oliver +22 more
TL;DR: These data identify metabolic heterogeneity within SCLC and suggest arginine deprivation as a subtype-specific therapeutic vulnerability for MYC-driven SclC.
Journal ArticleDOI
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
Katrin P. Guillen,Maihi Fujita,Andrew Butterfield,Sandra D. Scherer,Matthew A. Bailey,Zheng-Qing Chu,Yoko S. DeRose,Ling Zhao,Emilio Cortes-Sanchez,Chieh-Hsiang Yang,J. Toner,Guoying Wang,Yi Qiao,Xiaomeng Huang,Jeff Greenland,Jeffery M. Vahrenkamp,David H. Lum,Rachel E. Factor,Edward W. Nelson,Cindy B. Matsen,J. M. Poretta,Regina Rosenthal,Anna C. Beck,Saundra S. Buys,Christos Vaklavas,John Harris Ward,Randy L. Jensen,Kevin B. Jones,Zheqi Li,Steffi Oesterreich,Lacey E. Dobrolecki,Satya Pathi,Xing Yi Woo,Kristofer C. Berrett,Mark E. Wadsworth,Jeffrey H. Chuang,Michael Lewis,Gabor T. Marth,Jay Gertz,Katherine E. Varley,Bryan E. Welm,Alana L. Welm +41 more
TL;DR: In this article , a bank of human patient-derived xenografts and matched organoid cultures from tumors that represent the greatest unmet need: endocrine-resistant, treatment-refractory and metastatic breast cancers are reported.
Journal ArticleDOI
Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer.
Jeffery M. Vahrenkamp,Chieh Hsiang Yang,Adriana C. Rodriguez,Adriana C. Rodriguez,Aliyah Almomen,Kristofer C. Berrett,Kristofer C. Berrett,Alexis N. Trujillo,Katrin P. Guillen,Katrin P. Guillen,Bryan E. Welm,Elke A. Jarboe,Margit M. Janát-Amsbury,Jason Gertz,Jason Gertz +14 more
TL;DR: The results suggest phenotypic and molecular interplay between ER and GR in endometrial cancer and suggest that expression of GR is associated with poor prognosis.