B
Benjamin L. Witt
Researcher at University of Utah
Publications - 70
Citations - 1946
Benjamin L. Witt is an academic researcher from University of Utah. The author has contributed to research in topics: Biopsy & Medicine. The author has an hindex of 20, co-authored 64 publications receiving 1341 citations. Previous affiliations of Benjamin L. Witt include ARUP Laboratories & NorthShore University HealthSystem.
Papers
More filters
Journal ArticleDOI
MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition
Gurkan Mollaoglu,Matthew R. Guthrie,Stefanie Böhm,Johannes Brägelmann,Ismail Can,Paul M. Ballieu,Annika Marx,Julie George,Christine Heinen,Milind D. Chalishazar,Haixia Cheng,Abbie S. Ireland,Kendall E. Denning,Anandaroop Mukhopadhyay,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Timothy L. Mosbruger,Jun Wang,Jessica L. Kohan,Mohamed E. Salama,Benjamin L. Witt,Martin Peifer,Roman K. Thomas,Roman K. Thomas,Jason Gertz,Jane E. Johnson,Adi F. Gazdar,Robert J. Wechsler-Reya,Martin L. Sos,Trudy G. Oliver +29 more
TL;DR: It is shown that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.
Journal ArticleDOI
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate
Abbie S. Ireland,Alexi M. Micinski,David W. Kastner,Bingqian Guo,Sarah J. Wait,Kyle B. Spainhower,Christopher C. Conley,Opal S. Chen,Matthew R. Guthrie,Danny Soltero,Yi Qiao,Xiaomeng Huang,Szabolcs Tarapcsák,Siddhartha Devarakonda,Milind D. Chalishazar,Jason Gertz,Justin C. Moser,Gabor T. Marth,Sonam Puri,Benjamin L. Witt,Benjamin T. Spike,Trudy G. Oliver +21 more
TL;DR: It is revealed that mouse and human models with a time-series single-cell transcriptome analysis reveal that MYC drives dynamic evolution of SCLC subtypes, suggesting that genetics, cell of origin, and tumor cell plasticity determine SclC subtype.
Journal ArticleDOI
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Gurkan Mollaoglu,Alex Jones,Sarah J. Wait,Anandaroop Mukhopadhyay,Sangmin Jeong,Rahul Arya,Soledad A. Camolotto,Timothy L. Mosbruger,Chris Stubben,Christopher J. Conley,Arjun Bhutkar,Jeffery M. Vahrenkamp,Kristofer C. Berrett,Melissa H. Cessna,Thomas E. Lane,Benjamin L. Witt,Mohamed E. Salama,Jason Gertz,Kevin B. Jones,Eric L. Snyder,Trudy G. Oliver +20 more
TL;DR: Mouse models of lung cancer recapitulate humanNSCLC immune microenvironment and define the relationship between lineage‐defining transcription factors and squamous NSCLC and adenocarcinoma, revealing that this interplay also determines neutrophil recruitment.
Proceedings ArticleDOI
Abstract PO-120: MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
Abbie S. Ireland,Alexi M. Micinski,David W. Kastner,Bingqian Guo,Sarah J. Wait,Kyle B. Spainhower,Christopher C. Conley,Opal S. Chen,Matthew R. Guthrie,Danny Soltero,Yi Qiao,Xiaomeng Huang,Szabolcs Tarapcsák,Siddhartha Devarakonda,Milind D. Chalishazar,Jason Gertz,Justin C. Moser,Gabor T. Marth,Sonam Puri,Benjamin L. Witt,Benjamin T. Spike,Trudy G. Oliver +21 more
TL;DR: It is shown that the oncogene MYC drives the dynamic evolution of SCLC subtypes by activation of Notch signaling, and that molecular subsets of other cancer types may also represent dynamic stages of tumor evolution.
Journal ArticleDOI
The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology: a systematic review and meta-analysis.
TL;DR: A systematic review and meta-analysis of studies on the influence of ROSE on FNA adequacy found that on average, ROSE improves the adequacy rate by 12%, but there was considerable variability across studies.