Haixia Cheng

TL;DR: It is shown that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC.

TL;DR: The authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.

TL;DR: It is demonstrated that inhibition of HAT p300 by its selective inhibitor A-485 is a promising therapy for GHPA and could downregulate the expression or activity of several oncogenes, such as genes in the Pttg1, c-Myc, cAMP and PI3K/AKT/mTOR signaling pathways, which are crucial for PA tumorigenesis and progression.

TL;DR: Wang et al. as mentioned in this paper identified a cluster of stem-like SBC cells that tended to be distributed in the inferior part of the tumor, and they further found that this cell cluster is marked by cathepsin L (CTSL ), a gene involved in the packaging of telomere ends, and may be responsible for radioresistance.

TL;DR: In this paper , a comparative analysis of single-cell RNA sequencing data from 3 anterior pituitary glands and 21 PitNETs was performed to comprehensively reveal the origin and differentiation status of PitNET.