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Paul N. Ulrich
Researcher at University of Georgia
Publications - 17
Citations - 527
Paul N. Ulrich is an academic researcher from University of Georgia. The author has contributed to research in topics: Acidocalcisome & Vacuole. The author has an hindex of 11, co-authored 16 publications receiving 477 citations. Previous affiliations of Paul N. Ulrich include Houghton College & Georgia State University.
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Journal ArticleDOI
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes
TL;DR: Storage of phosphate and cations may represent the ancestral physiological function of acidocalcisomes, with cation and pH homeostasis and osmoregulatory functions derived following the divergence of prokaryotes and eukaryotes.
Journal ArticleDOI
Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells.
Guozhong Huang,Paul N. Ulrich,Melissa Storey,Darryl Johnson,Julie Tischer,Javier A. Tovar,Silvia N.J. Moreno,Ron Orlando,Roberto Docampo +8 more
TL;DR: A comprehensive insight is provided into the unique composition of acidocalcisomes of T. brucei, an important eukaryotic pathogen, and direct evidence that acidocalCisomes are especially adapted for the accumulation of polyphosphate is provided.
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Identification of Contractile Vacuole Proteins in Trypanosoma cruzi
Paul N. Ulrich,Veronica Jimenez,Miyoung Park,Vicente de Paulo Martins,James Atwood,Kristen Moles,Dalis E Collins,Peter Rohloff,Rick L. Tarleton,Silvia N.J. Moreno,Ron Orlando,Roberto Docampo +11 more
TL;DR: The results demonstrate the utility of combining subcellular fractionation, proteomic analysis, and bioinformatic approaches for localization of organellar proteins that are difficult to detect with whole cell methodologies.
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Trypanosoma brucei Vacuolar Transporter Chaperone 4 (TbVtc4) Is an Acidocalcisome Polyphosphate Kinase Required for in Vivo Infection
TL;DR: It is reported that TbVtc4 (VTC4 ortholog of Trypanosoma brucei) encodes, in contrast, a short chain polyP kinase that localizes to acidocalcisomes, underscoring the relevance of polyP in osmoregulation.
Journal ArticleDOI
Target of Rapamycin (TOR)-like 1 Kinase Is Involved in the Control of Polyphosphate Levels and Acidocalcisome Maintenance in Trypanosoma brucei
Teresa Cristina Leandro de Jesus,Teresa Cristina Leandro de Jesus,Renata Rosito Tonelli,Sheila Cristina Nardelli,Leonardo Augusto,Maria Cristina M. Motta,Wendell Girard-Dias,Kildare Miranda,Paul N. Ulrich,Veronica Jimenez,Antonio Barquilla,Miguel Navarro,Roberto Docampo,Sergio Schenkman +13 more
TL;DR: The results suggest that TbTOR-like 1 might be involved in the control of acidocalcisome and polyphosphate metabolism in T. brucei.