K
Kildare Miranda
Researcher at Federal University of Rio de Janeiro
Publications - 104
Citations - 4048
Kildare Miranda is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Acidocalcisome & Medicine. The author has an hindex of 32, co-authored 96 publications receiving 3495 citations. Previous affiliations of Kildare Miranda include State University of Norte Fluminense & University of Georgia.
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Journal ArticleDOI
Acidocalcisomes ? conserved from bacteria to man
Roberto Docampo,Roberto Docampo,Wanderley de Souza,Kildare Miranda,Kildare Miranda,Peter Rohloff,Silvia N.J. Moreno,Silvia N.J. Moreno +7 more
TL;DR: Acidocalcisomes were first described in trypanosomatids and have been characterized in most detail in these species, and are linked with several functions, including storage of cations and phosphorus, polyphosphate metabolism, calciumHomeostasis, maintenance of intracellular pH homeostasis and osmoregulation.
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Vesicular Polysaccharide Export in Cryptococcus neoformans Is a Eukaryotic Solution to the Problem of Fungal Trans-Cell Wall Transport
Marcio L. Rodrigues,Leonardo Nimrichter,Débora L. Oliveira,Susana Frases,Kildare Miranda,Oscar Zaragoza,Mauricio A. Álvarez,Antonio Nakouzi,Marta Feldmesser,Arturo Casadevall +9 more
TL;DR: It is demonstrated that C. neoformans produces extracellular vesicles during in vitro growth and animal infection and implies a novel mechanism for the release of the major virulence factor of C. Neoformans whereby polysaccharide packaged in lipid vesicle crosses the cell wall and the capsule network to reach the Extracellular environment.
Journal ArticleDOI
Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth.
Marcio L. Rodrigues,Luiz R. Travassos,Kildare Miranda,Anderson J. Franzen,Sonia Rozental,Wanderley de Souza,Celuta S. Alviano,Eliana Barreto-Bergter +7 more
TL;DR: The present data suggest that the cryptococcal β-glucosylceramide is a fungal antigen that plays a role on the cell wall synthesis and yeast budding and that antibodies raised against this component are inhibitory in vitro.
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Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans
Gabriele Vargas,Juliana Dutra B. Rocha,Débora L. Oliveira,Priscila C. Albuquerque,Susana Frases,Suelen Silvana dos Santos,Joshua Daniel Nosanchuk,Andre M. O. Gomes,Lia Carolina Soares Medeiros,Kildare Miranda,Tiago J. P. Sobreira,Ernesto S. Nakayasu,Emma Arigi,Arturo Casadevall,Allan J. Guimarães,Marcio L. Rodrigues,Marcio L. Rodrigues,Celio Geraldo Freire-de-Lima,Igor C. Almeida,Leonardo Nimrichter +19 more
TL;DR: The results demonstrate that C. albicans EV were immunologically active and could potentially interfere with the host responses in the setting of invasive candidiasis.
Journal ArticleDOI
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole
Kildare Miranda,Douglas A. Pace,Roxana Cintron,Juliany Cola Fernandes Rodrigues,Juliany Cola Fernandes Rodrigues,Jianmin Fang,Alyssa Smith,Peter Rohloff,Elvis Coelho,Felix De Haas,Wanderley de Souza,Isabelle Coppens,L. David Sibley,Silvia N.J. Moreno +13 more
TL;DR: A novel organelle is described and characterize in T. gondii tachyzoites, which is visible by light microscopy and possesses a broad similarity to the plant vacuole and appears to have protective effects against salt stress potentially linked to its sodium transport activity.