Kath Smith

TL;DR: It is suggested that increased dosage of chromosome 17q and 12 gene(s) provides a selective advantage for the propagation of undifferentiated hES cells in transplantation therapies in which the use of aneuploid cells could be detrimental.

TL;DR: It is proposed that the changes observed in HESCs in culture reflect tumorigenic events that occur in vivo, particularly in testicular germ cell tumors, supporting a link between culture adaptation and malignancy.

TL;DR: It is shown that the gene expression programmes of the adapted cells partially reflected their aberrant karyotype, but also resulted from a failure in X-inactivation, emphasizing the importance in adaptation of karyotypically silent epigenetic changes.

TL;DR: It is shown that mouse EC cells can also function as donors of reprogramming factors and could serve as a model for ES cells in this respect, since they share many of the key characteristics of ES cells, such as pluripotency.

TL;DR: FISH is very useful in classifying equivocal conjunctival melanocytic lesions, especially those with atypical junctional activity and naevoid melanocytics proliferations of the conjunctiva.