S
Soila Sukupolvi-Petty
Researcher at Washington University in St. Louis
Publications - 19
Citations - 2922
Soila Sukupolvi-Petty is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Dengue virus & Monoclonal antibody. The author has an hindex of 17, co-authored 17 publications receiving 2711 citations.
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Journal ArticleDOI
The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity
Martina Beltramello,Katherine L. Williams,Cameron P. Simmons,Annalisa Macagno,Luca Simonelli,Nguyen Than Ha Quyen,Soila Sukupolvi-Petty,Erika Navarro-Sanchez,Paul R. Young,Aravinda M. de Silva,Félix A. Rey,Luca Varani,Stephen S. Whitehead,Michael S. Diamond,Eva Harris,Antonio Lanzavecchia,Federica Sallusto +16 more
TL;DR: These findings reveal an unexpected degree of cross-reactivity in human antibodies against DENV and illustrate the potential for an antibody-based therapy to control severe dengue.
Journal ArticleDOI
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
Shee-Mei Lok,Kostyuchenko,Grant E. Nybakken,Heather A. Holdaway,Anthony J. Battisti,Soila Sukupolvi-Petty,Dagmar Sedlak,Daved H. Fremont,Paul R. Chipman,John T. Roehrig,Michael S. Diamond,Richard J. Kuhn,Michael G. Rossmann +12 more
TL;DR: The monoclonal antibody 1A1D-2 has been shown to strongly neutralize dengue virus serotypes 1, 2 and 3, primarily by inhibiting attachment to host cells, and a crystal structure of its antigen binding fragment (Fab) complexed with domain III of the viral envelope glycoprotein, E, showed that the epitope would be partially occluded in the known structure of the mature d Dengue virus.
Journal ArticleDOI
Antibody recognition and neutralization determinants on domains I and II of West Nile Virus envelope protein.
Theodore Oliphant,Grant E. Nybakken,Michael Engle,Qing Xu,Christopher A. Nelson,Soila Sukupolvi-Petty,Anantha Marri,Bat-El Lachmi,Udy Olshevsky,Daved H. Fremont,Theodore C. Pierson,Michael S. Diamond +11 more
TL;DR: DI and DII MAbs protect against WNV infection in mice, albeit with lower efficiency than DIII-specific neutralizing MAbs, and several of the neutralizing epitopes were located in solvent-inaccessible positions.
Journal ArticleDOI
Type- and Subcomplex-Specific Neutralizing Antibodies against Domain III of Dengue Virus Type 2 Envelope Protein Recognize Adjacent Epitopes
Soila Sukupolvi-Petty,S. Kyle Austin,Whitney E. Purtha,Theodore Oliphant,Grant E. Nybakken,Jacob J. Schlesinger,John T. Roehrig,Gregory D. Gromowski,Alan D.T. Barrett,Daved H. Fremont,Michael S. Diamond +10 more
TL;DR: Overall, the experiments define adjacent and structurally distinct epitopes on DIII of DENV-2 which elicit type-specific, subcomplex- specific, and cross-reactive antibodies with different neutralizing potentials.
Journal ArticleDOI
The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1
Bimmi Shrestha,James D. Brien,Soila Sukupolvi-Petty,S. Kyle Austin,Melissa A. Edeling,Taekyung Kim,Katie M. O'Brien,Christopher A. Nelson,Syd Johnson,Daved H. Fremont,Michael S. Diamond +10 more
TL;DR: A complex structural epitope on DIII of DENV-1 that can be recognized by protective antibodies with therapeutic potential is defined and sequence variation in DIII alone failed to explain disparities in neutralizing potential of MAbs among different genotypes.