P
Paul T. Morrison
Researcher at Harvard University
Publications - 31
Citations - 4338
Paul T. Morrison is an academic researcher from Harvard University. The author has contributed to research in topics: FLP-FRT recombination & Recombination. The author has an hindex of 22, co-authored 31 publications receiving 4265 citations. Previous affiliations of Paul T. Morrison include University of Oslo & Western General Hospital.
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Journal ArticleDOI
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
C.E. Bronner,Sean M. Baker,Paul T. Morrison,Graham Warren,L.G. Smith,Lescoe Mk,Michael F. Kane,Earabino C,Lipford J,Annika Lindblom +9 more
TL;DR: It is reported that a human gene encoding a protein, hMLHl (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.
Journal ArticleDOI
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition.
TL;DR: C-Met when mutated or over-expressed in malignant cells serves as an important therapeutic target and the most recent data in terms of inhibition of c-Met and downstream signal transduction pathways is summarized.
Journal ArticleDOI
Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations
Richard D. Kolodner,N. R. Hall,Lipford J,Michael F. Kane,M.R.S. Rao,Paul T. Morrison,Lori J. Wirth,Paul J. Finan,John Burn,P Chapman +9 more
TL;DR: Methods have been used to analyze two large HNPCC kindreds exhibiting features of the Muir-Torre syndrome and demonstrate that cancer susceptibility is due to the inheritance of a frameshift mutation in the MSH2 gene in one family and a nonsense mutation in that family's gene in the other family.
Journal Article
Structure of the Human MLH1 Locus and Analysis of a Large Hereditary Nonpolyposis Colorectal Carcinoma Kindred for mlh1 Mutations
Richard D. Kolodner,N. R. Hall,Lipford J,Michael F. Kane,Paul T. Morrison,P. J. Finan,John Burn,P Chapman,Earabino C,E. Merchant +9 more
TL;DR: It is demonstrated that cancer susceptibility in this family is due to the inheritance of a frame shift mutation in the hMLH1 gene.
Journal ArticleDOI
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
Anne Lise Børresen,Ragnhild A. Lothe,Gunn Iren Meling,Sigrid Lystad,Paul T. Morrison,Lipford J,Michael F. Kane,Torleiv O. Rognum,Richard D. Kolodner,Richard D. Kolodner +9 more
TL;DR: It is demonstrated that a considerable proportion of sporadic colorectal cancers with microsatellite instability, have somatic mutations in the hMSH2 gene.