E
Earabino C
Researcher at Harvard University
Publications - 3
Citations - 2328
Earabino C is an academic researcher from Harvard University. The author has contributed to research in topics: MLH1 & DNA mismatch repair. The author has an hindex of 3, co-authored 3 publications receiving 2290 citations.
Papers
More filters
Journal ArticleDOI
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
C.E. Bronner,Sean M. Baker,Paul T. Morrison,Graham Warren,L.G. Smith,Lescoe Mk,Michael F. Kane,Earabino C,Lipford J,Annika Lindblom +9 more
TL;DR: It is reported that a human gene encoding a protein, hMLHl (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.
Journal Article
Structure of the Human MLH1 Locus and Analysis of a Large Hereditary Nonpolyposis Colorectal Carcinoma Kindred for mlh1 Mutations
Richard D. Kolodner,N. R. Hall,Lipford J,Michael F. Kane,Paul T. Morrison,P. J. Finan,John Burn,P Chapman,Earabino C,E. Merchant +9 more
TL;DR: It is demonstrated that cancer susceptibility in this family is due to the inheritance of a frame shift mutation in the hMLH1 gene.
Journal ArticleDOI
Human mismatch repair genes and their association with hereditary non-polyposis colon cancer.
Richard D. Kolodner,N. R. Hall,Lipford J,Michael F. Kane,M.R.S. Rao,Paul T. Morrison,Lori J. Wirth,P. J. Finan,John Burn,P Chapman,Earabino C,E. Merchant,D. T. Bishop,Judy Garber,C.E. Bronner,Sean M. Baker,Graham Warren,L.G. Smith,Annika Lindblom,Pia Tannergård,R J Bollag,A R Godwin,D.C. Ward,Magnus Nordenskjöld,R. M. Liskay,Neal G. Copeland,Nancy A. Jenkins,Mary Kay Lescoe,A. Ewel,S. Lee,Jack D. Griffith,Richard Fishel +31 more
TL;DR: Hereditary non-polyposis colon cancer (HNPCC) may affect up to 1 in 200 people in industrialized nations and four genes have been identified in which inherited mutations appear to cause HNPCC.