R
Ragnhild A. Lothe
Researcher at Oslo University Hospital
Publications - 308
Citations - 17453
Ragnhild A. Lothe is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 70, co-authored 295 publications receiving 15506 citations. Previous affiliations of Ragnhild A. Lothe include Prevention Institute & University of Oslo.
Papers
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Journal Article
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.
Ragnhild A. Lothe,Päivi Peltomäki,Gunn Iren Meling,Lauri A. Aaltonen,Minna Nyström-Lahti,Lea Pylkkänen,Ketil Heimdal,Tone Ikdahl Andersen,Pal Mller,Torleiv O. Rognum,Sophie D. Fosså,Tor Haldorsen,Fr ydis Langmark,Anton Br gger,Albert de la Chapelle,Anne Lise B rresen +15 more
TL;DR: Interestingly, no significant association was found between RER+ tumors and a general familial clustering of cancer, indicating that this phenomenon may be specific to certain types of tumors.
Journal ArticleDOI
Epigenetic and genetic features of 24 colon cancer cell lines.
Deeqa Ahmed,Peter W. Eide,Ina A. Eilertsen,Stine A. Danielsen,Mette Eknæs,Merete Hektoen,Guro Elisabeth Lind,Guro Elisabeth Lind,Ragnhild A. Lothe,Ragnhild A. Lothe +9 more
TL;DR: Molecular features of a large number of colon cancer cell lines are presented to aid the selection of suitable in vitro models for descriptive and functional research.
Journal Article
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.
Päivi Peltomäki,Ragnhild A. Lothe,Lauri A. Aaltonen,Lea Pylkkänen,Minna Nyström-Lahti,Raquel Seruca,Leonor David,Ruth Holm,David Ryberg,Aage Haugen +9 more
TL;DR: The findings suggest that the cancers belonging to the hereditary non-polyposis colorectal carcinoma tumor spectrum may have essential pathogenetic steps in common, including a tendency to multiple replication errors.
Journal ArticleDOI
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
Anita Sveen,Anita Sveen,Sami Kilpinen,A Ruusulehto,Ragnhild A. Lothe,Ragnhild A. Lothe,Rolf Inge Skotheim,Rolf Inge Skotheim +7 more
TL;DR: This review provides an overview of aberrant RNA splicing and its regulation in cancer, and proposes 24 novel cancer-critical splicing factors predicted from somatic mutations.
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Intradermal ras peptide vaccination with granulocyte‐macrophage colony‐stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
Marianne Klemp Gjertsen,Trond Buanes,Arne R. Rosseland,Arne Bakka,Ivar P. Gladhaug,Odd Søreide,Jon Amund Eriksen,Mona Moller,Ingebjørg Baksaas,Ragnhild A. Lothe,Ingvil Saeterdal,Gustav Gaudernack +11 more
TL;DR: Although a limited number of patients were included in this study, the association between prolonged survival and an immune response against the vaccine suggests that a clinical benefit of ras peptide vaccination may be obtained for this group of patients.