P
Paul T. Ranum
Researcher at Children's Hospital of Philadelphia
Publications - 25
Citations - 897
Paul T. Ranum is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene & Hearing loss. The author has an hindex of 9, co-authored 16 publications receiving 572 citations. Previous affiliations of Paul T. Ranum include Roy J. and Lucille A. Carver College of Medicine & University of Minnesota.
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Journal ArticleDOI
Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss
Christina M. Sloan-Heggen,Amanda O. Bierer,A. Eliot Shearer,Diana L. Kolbe,Carla Nishimura,Kathy L. Frees,Sean S. Ephraim,Seiji B. Shibata,Kevin T. Booth,Colleen A. Campbell,Paul T. Ranum,Amy E. Weaver,E. Ann Black-Ziegelbein,Donghong Wang,Hela Azaiez,Richard J.H. Smith,Richard J.H. Smith +16 more
TL;DR: Findings support the more efficient utilization of medical resources through the development of evidence-based algorithms for the diagnosis of hearing loss through targeted genomic enrichment and massively parallel sequencing.
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Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing.
Paul T. Ranum,Paul T. Ranum,Alexander T. Goodwin,Hidekane Yoshimura,Hidekane Yoshimura,Diana L. Kolbe,William D. Walls,Jin-Young Koh,David Z.Z. He,Richard J.H. Smith,Richard J.H. Smith +10 more
TL;DR: A refined view of transcription in the organ of Corti improves the understanding of the biology of hearing and deafness and provides insights into the expression profiles of these cells.
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RNA Interference Prevents Autosomal-Dominant Hearing Loss
Seiji B. Shibata,Paul T. Ranum,Paul T. Ranum,Hideaki Moteki,Hideaki Moteki,Bifeng Pan,Alexander T. Goodwin,Shawn S. Goodman,Paul J. Abbas,Jeffrey R. Holt,Richard J.H. Smith +10 more
TL;DR: It is shown that a single intracochlear injection of an artificial microRNA carried in a viral vector can slow progression of hearing loss for up to 35 weeks in the Beethoven mouse, a murine model of non-syndromic human deafness caused by a dominant gain-of-function mutation in Tmc1 (transmembrane channel-like 1).
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Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation
Hidekane Yoshimura,Hidekane Yoshimura,Seiji B. Shibata,Paul T. Ranum,Paul T. Ranum,Richard J.H. Smith +5 more
TL;DR: The feasibility of a combined round window membrane injection and semi-circular canal fenestration technique in the adult cochlea is demonstrated and its use will facilitate studies using cochlear gene therapy in murine models of hearing loss over a wide range of time points.
Journal ArticleDOI
CDKL5 Regulates Flagellar Length and Localizes to the Base of the Flagella in Chlamydomonas
TL;DR: Two mutations in LF5, which encodes a protein kinase orthologous to human CDKL5, cause abnormally long flagella in Chlamydomonas.