This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.

P38 inhibitors and methods of use thereof

Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

Pharma-informatics system

Publisher Summary This chapter provides information on the chemistry and pharmacology and physicochemical properties of barbiturates, along with the tautomerism and solvation of the barbituric acid ring. Barbituric acid exists in the solid state in the trioxo structure. NMR investigation of the oxo-hydroxy equilibrium indicates that only the oxo form is present in a solution in anhydrous DMSO. Several spectral properties of the barbituric acid are discussed using UV spectra, infrared and Raman spectroscopy, 1 H-NMR spectroscopy, 13 C-NMR spectroscopy, and mass spectrometry. In the crystalline state, barbiturates show several modes of intermolecular hydrogen bonding, which differ by the number of hydrogen bonds formed between the NH and CO groups. These hydrogen bonds are responsible for layer packing in the crystal lattice. Weak intermolecular van der Waals interactions of carbonyl groups are also responsible for the three-dimensional packing of the molecules in the crystal structure.

Recent Progress in Barbituric Acid Chemistry

Enaminones in heterocyclic synthesis

Knoevenagel condensation reactions in an ionic liquid

The synthesis of pyridine derivatives from 3‐formylchromone

A general synthesis of selectively 6-(trifluoromethyl)-substitued 2(1H)-pyridinones is described. Further transformation of one of these compounds leads to the new CF3-containing potassium-channel openers 2a and 2b.

Synthesis of selectively trifluoromethylated pyridine derivaties as potential antihypertensives

The invention relates to novel lactones, especially benzofuranones of the general formula ##STR1## in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by two monovalent hydrocarbon radicals, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufacture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments and/or for the manufacture of pharmaceutical preparations.

Benzofuran-2(3H)-ones used as anti-inflammatory agents

Benzofurans or 2,3-dihydrobenzofurans of the formula ##STR1## in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group disubstituted by a bivalent aliphatic radical which is optionally interrupted by at least one hetero atom, and the aromatic ring may be additionally substituted, and the salts thereof, have anti-inflammatory and/or analgesic activities.

Heterocyclicamino containing benzofurans and 2,3-dihydrobenzofurans, compositions and use

Novel 4-acylresorcinol ethers of the formula ##STR1## in which R 1 is lower alkyl, alk is a hydroxyalkylene radical which can be interrupted by oxygen and R 2 is 5-tetrazolyl, it being possible for the ring A to be additionally substituted by a lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy and/or halogen and for the ring B to be additionally substituted by lower alkyl, lower alkanoyl, lower alkoxy, lower alkoxycarbonyl, carboxyl, cyano, carbamyl, halogen and/or trifluoromethyl, and salts thereof have antiallergic properties and can be used as active compounds for medicaments. They are prepared by methods known as per se.

Paul Wenk

Papers

The synthesis of pyridine derivatives from 3‐formylchromone

Synthesis of selectively trifluoromethylated pyridine derivaties as potential antihypertensives

Benzofuran-2(3H)-ones used as anti-inflammatory agents

Heterocyclicamino containing benzofurans and 2,3-dihydrobenzofurans, compositions and use

N-(substituted phenyl) tetrazol-5-yl carboxamides and anti-allergic use thereof