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Paula A. Zacharowski
Researcher at Queen Mary University of London
Publications - 15
Citations - 725
Paula A. Zacharowski is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Reperfusion injury & Sepsis. The author has an hindex of 11, co-authored 15 publications receiving 684 citations.
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Journal ArticleDOI
The fibrin-derived peptide Bβ 15-42 protects the myocardium against ischemia-reperfusion injury
Peter Petzelbauer,Paula A. Zacharowski,Yasuhiro Miyazaki,Peter Friedl,Georg Wickenhauser,Francis J. Castellino,Marion Gröger,Klaus Wolff,Kai Zacharowski +8 more
TL;DR: In this article, a fibrin-derived peptide, Bbeta15-42, was shown to reduce leukocyte infiltration, infarct size and subsequent scar formation in acute or chronic rat models of myocardial ischemia-reperfusion injury.
Journal ArticleDOI
Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome
Kai Zacharowski,Paula A. Zacharowski,Alexander Koch,Aida Baban,Nguyen Tran,Reinhard Berkels,Claudia Papewalis,Klaus Schulze-Osthoff,Pascal Knuefermann,Ulrich Zähringer,Ralf R. Schumann,Valeria Rettori,Samuel M. McCann,Stefan R. Bornstein +13 more
TL;DR: It is demonstrated that TLR-4 is a key mediator in the crosstalks between the innate immune system and the endocrine stress response and could contribute to the underlying mechanisms of impaired adrenal stress response in patients with bacterial sepsis.
Journal ArticleDOI
Impaired adrenal stress response in Toll-like receptor 2-deficient mice.
Stefan R. Bornstein,Paula A. Zacharowski,Ralf R. Schumann,Andreas Barthel,Nguyen Tran,Claudia Papewalis,Valeria Rettori,Samuel M. McCann,Klaus Schulze-Osthoff,Werner A. Scherbaum,Jörg Tarnow,Kai Zacharowski +11 more
TL;DR: It is demonstrated that TLR-2 deficiency in mice is associated with reduced plasma corticosterone levels and marked cellular alterations in adrenocortical tissue, and a link between the innate immune system and the endocrine stress response is demonstrated.
Journal ArticleDOI
Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction.
TL;DR: The pathogenesis of reperfusion injury is summarized, detailing the role of fibrin(ogen) and its derivatives, and a new concept for fibrIn derivatives as potential targets for reperfusions therapy is introduced.
Journal ArticleDOI
Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury.
Jan Mersmann,Reinhard Berkels,Paula A. Zacharowski,Nguyen Tran,Alexander Koch,Kazuma Iekushi,Stefanie Dimmeler,Tiago Granja,Olaf Boehm,William C. Claycomb,Kai Zacharowski +10 more
TL;DR: Testing whether preconditioning with a toll-like receptor (TLR) 2 agonist protects against myocardial ischemia and reperfusion by interfering with chemokine CXCL1 release from cardiomyocytes found that preconditioning by Pam3CSK4 reduced infarct size and troponin T release and resulted in an improved cardiac function.