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Paula R. Clemens
Researcher at University of Pittsburgh
Publications - 131
Citations - 7474
Paula R. Clemens is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Duchenne muscular dystrophy & Muscular dystrophy. The author has an hindex of 37, co-authored 117 publications receiving 6381 citations. Previous affiliations of Paula R. Clemens include United States Department of Veterans Affairs & Baylor College of Medicine.
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Journal ArticleDOI
Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management
David J. Birnkrant,Katharine Bushby,Carla M. Bann,Susan D. Apkon,Angela Blackwell,David Brumbaugh,Laura E. Case,Paula R. Clemens,Stasia Hadjiyannakis,Shree Pandya,Natalie Street,Jean Tomezsko,Kathryn R. Wagner,Leanne M Ward,David R. Weber +14 more
TL;DR: Care considerations for diagnosis of DMD and neuromuscular, rehabilitation, endocrine (growth, puberty, and adrenal insufficiency), and gastrointestinal (including nutrition and dysphagia) management are presented.
Journal ArticleDOI
A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase
TL;DR: The development of a new adenoviral vector that has all viral coding sequences removed is reported, and independent expression of both genes in primary mdx (dystrophin-deficient) muscle cells is demonstrated.
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A Randomized Study of Alglucosidase Alfa in Late-Onset Pompe's Disease
Ans T. van der Ploeg,Paula R. Clemens,Deyanira Corzo,Diana M. Escolar,Julaine Florence,Geert Jan Groeneveld,Serge Herson,Priya S. Kishnani,Pascal Laforêt,Stephen Lake,Dale J. Lange,Robert T. Leshner,J. Mayhew,Claire Morgan,Kenkichi Nozaki,Dorothy J. Park,Alan Pestronk,Barry E. Rosenbloom,Alison Skrinar,Carine I. van Capelle,Nadine Ame van der Beek,Melissa P. Wasserstein,Sasa A. Zivkovic +22 more
TL;DR: Treatment with alglucosidase alfa was associated with improved walking distance and stabilization of pulmonary function over an 18-month period, and this study population, which is characterized by progressive muscle weakness and loss of respiratory function.
Journal ArticleDOI
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
Jeremy S. Tilstra,Andria Rasile Robinson,Jin Wang,Siobhán Q. Gregg,Cheryl L. Clauson,Daniel P. Reay,Luigi Aurelio Nasto,Claudette M. St. Croix,Arvydas Usas,Nam Vo,Johnny Huard,Paula R. Clemens,Donna B. Stolz,Denis C. Guttridge,Simon C. Watkins,George A. Garinis,Yinsheng Wang,Laura J. Niedernhofer,Laura J. Niedernhofer,Paul D. Robbins,Paul D. Robbins +20 more
TL;DR: Results indicate that the mechanism by which DNA damage drives aging is due in part to NF-κB activation and IKK/NF-κBs inhibitors are sufficient to attenuate this damage and could provide clinical benefit for degenerative changes associated with accelerated aging disorders and normal aging.
Journal ArticleDOI
Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection
Anthony Kanai,Linda L. Pearce,Paula R. Clemens,Lori A. Birder,Michelle M. VanBibber,So Young Choi,William C. de Groat,Jim Peterson +7 more
TL;DR: It is functionally demonstrate the presence of a NOS in cardiac mitochondria and suggests a modulatory role for NO in oxidative phosphorylation and, in turn, myocardial contractility.