Pauline Dergham

TL;DR: It is demonstrated that inactivation of Rho or its downstream target Rho-associated kinase (ROK) stimulated neurite growth in primary cells of cortical neurons plated on myelin or chondroitin sulfate proteoglycan substrates, providing evidence that the Rho signaling pathway is a potential target for therapeutic interventions after spinal cord injury.

TL;DR: It is reported that injured axons regrow directly on complex inhibitory substrates when Rho GTPase is inactivated, indicating that targeting signaling mechanisms converging to Rho stimulates axon regeneration on inhibitory CNS substrates.

TL;DR: Oligodendrocyte‐myelin glycoprotein is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglions neurons; and from NG108 and PC12 cells.

TL;DR: It is demonstrated that BA-210, a cell-permeable fusion protein derived from C3 transferase, formulated in fibrin sealant and delivered topically onto the dura matter, diffuses into the spinal cord and inactivates Rho in a dose-dependent manner.

TL;DR: The studies indicate that the small GTPase Rho is an important intracellular target for promoting axon regrowth after injury, and reveal the potential for a new, straightforward technique to promote axon regeneration.