P
Peter E. Braun
Researcher at McGill University
Publications - 93
Citations - 7896
Peter E. Braun is an academic researcher from McGill University. The author has contributed to research in topics: Myelin & 2',3'-Cyclic-nucleotide 3'-phosphodiesterase. The author has an hindex of 40, co-authored 93 publications receiving 7681 citations.
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Journal ArticleDOI
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth.
TL;DR: It is established that MAG is a significant, and possibly the major, inhibitor in CNS myelin; this has broad implications for axonal regeneration in the injured mammalian CNS.
Journal ArticleDOI
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Corinna Lappe-Siefke,Sandra Goebbels,Michel Gravel,Eva Nicksch,John H.S. Lee,Peter E. Braun,Ian R. Griffiths,Klaus-Armin Nave +7 more
TL;DR: It is shown that Cnp1, which encodes 2′,3′-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly, and the chief function of glia in supporting axonal integrity can thus be completely uncoupled from its function in maintaining compact myelin.
Book ChapterDOI
Proteins of Myelin
TL;DR: The protein composition of CNS myelin is relatively simple, with two protein fractions comprising 60–80% of the total membrane protein.
Journal ArticleDOI
A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord
TL;DR: A novel therapeutic vaccine approach is presented in which the animals' own immune system is stimulated to produce polyclonal antibodies that block myelin-associated inhibitors without producing any detrimental cellular inflammatory responses, and adult mice immunized in this manner showed extensive regeneration of large numbers of axons of the corticospinal tracts.
Journal ArticleDOI
Myelin-Associated Glycoprotein Is the Antigen for a Monoclonal IgM in Polyneuropathy
TL;DR: It is demonstrated that the antigen for this antibody is a specific glycop protein component of myelin, referred to as myelin‐associated glycoprotein (MAG), which cross‐reacted with MAG from bovine CNS, but not from rabbit, rat, or mouse.