P
Pauline E. Chugh
Researcher at University of North Carolina at Chapel Hill
Publications - 12
Citations - 846
Pauline E. Chugh is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Kaposi's sarcoma-associated herpesvirus & Innate immune system. The author has an hindex of 11, co-authored 12 publications receiving 736 citations. Previous affiliations of Pauline E. Chugh include Henry M. Jackson Foundation for the Advancement of Military Medicine.
Papers
More filters
Journal ArticleDOI
Potential pitfalls in microRNA profiling
Pauline E. Chugh,Dirk P. Dittmer +1 more
TL;DR: This review addresses some of the advantages and potential pitfalls of the currently available methods for miRNA expression profiling and discusses isomiRNAs, comparison of different profiling platforms, normalization strategies, and issues with regard to sample preparation and experimental analyses.
Journal ArticleDOI
Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.
Pauline E. Chugh,Sang Hoon Sin,Sezgin Özgür,David H. Henry,Prema Menezes,Jack D. Griffith,Joseph J. Eron,Blossom Damania,Dirk P. Dittmer +8 more
TL;DR: It is suggested that exosomes derived from KSHV-associated malignancies are functional and contain a distinct subset of miRNAs, which could represent candidate biomarkers of disease and may contribute to the paracrine phenotypes that are a characteristic of KS.
Journal ArticleDOI
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation
Daisuke Yamane,David R. McGivern,Eliane Wauthier,Min Kyung Yi,Victoria J. Madden,Christoph Welsch,Iris Antes,Yahong Wen,Pauline E. Chugh,Charles E. McGee,Douglas G. Widman,Ichiro Misumi,Sibali Bandyopadhyay,Seungtaek Kim,Tetsuro Shimakami,Tsunekazu Oikawa,Jason K. Whitmire,Mark T. Heise,Dirk P. Dittmer,C. Cheng Kao,Stuart M. Pitson,Alfred H. Merrill,Lola M. Reid,Stanley M. Lemon +23 more
TL;DR: It is shown that multiple hepatitis C virus genotypes are exquisitely sensitive to oxidative membrane damage, a property distinguishing them from other pathogenic RNA viruses, and that the typical, wild-type HCV replicase is uniquely regulated by lipid peroxidation.
Journal ArticleDOI
Interferon-γ Production by Neutrophils during Bacterial Pneumonia in Mice
Mitsuhiro Yamada,John C. Gomez,Pauline E. Chugh,Clifford A. Lowell,Mary C. Dinauer,Mary C. Dinauer,Dirk P. Dittmer,Claire M. Doerschuk +7 more
TL;DR: Differential expression by neutrophils of microRNAs that target the 3' untranslated region of the IFN-γ gene may contribute to the pathogen-specific regulation of translation.
Journal ArticleDOI
Expression Profile of MicroRNAs in Epstein-Barr Virus-Infected AGS Gastric Carcinoma Cells
TL;DR: The microRNA expression in several EBV-infected AGS gastric carcinoma cell lines was determined and infected cells expressed the viral BamHI A rightward transcript (BART) miRNAs at high levels and had consistently decreased expression of a small fraction of cellular miRNAAs with specific downregulation of tumor suppressor miRNas.