B
Blossom Damania
Researcher at University of North Carolina at Chapel Hill
Publications - 196
Citations - 9447
Blossom Damania is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Primary effusion lymphoma & Kaposi's sarcoma-associated herpesvirus. The author has an hindex of 50, co-authored 178 publications receiving 8206 citations. Previous affiliations of Blossom Damania include University of Pennsylvania & Harvard University.
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Journal ArticleDOI
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
TL;DR: It is demonstrated that the pathogenic human herpesvirus Kaposi's sarcoma-associated herpesv virus (KSHV) encodes an array of 11 distinct miRNAs, all of which are expressed at readily detectable levels in latently KSHV infected cells.
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Infectious agents and cancer: criteria for a causal relation.
Joseph S. Pagano,Martin J. Blaser,Marie Annick Buendia,Blossom Damania,Kamel Khalili,Nancy Raab-Traub,Bernard Roizman +6 more
TL;DR: Despite the potent oncogenic properties of some strains of human adenovirus in tissue culture and animals the virus has not been linked with any human cancers and is likely that more agents and cancers have yet to be implicated in human cancer.
Journal ArticleDOI
The cGAS-STING Defense Pathway and Its Counteraction by Viruses
Zhe Ma,Blossom Damania +1 more
TL;DR: The balance between host immune control and viral immune evasion is pivotal to viral pathogenesis, and the balance is discussed in the context of the cGAS-STING innate immune pathway.
Journal ArticleDOI
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy
Yu Lei,Haitao Wen,Yanbao Yu,Debra J. Taxman,Lu Zhang,Douglas G. Widman,Karen V. Swanson,Kwun Wah Wen,Blossom Damania,Christopher Brooks Moore,Patrick M. Giguère,David P. Siderovski,John Hiscott,Babak Razani,Clay F. Semenkovich,Xian Chen,Jenny P.-Y. Ting +16 more
TL;DR: This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM, which has similar functions as NLRX1 by inhibiting RLR-induced IFN-I but promoting autophagy.
Journal ArticleDOI
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses
Zhe Ma,Sarah R. Jacobs,John A. West,Charles M. Stopford,Zhigang Zhang,Zoe H. Davis,Glen N. Barber,Britt A. Glaunsinger,Dirk P. Dittmer,Blossom Damania +9 more
TL;DR: This study is the first report identifying multiple viral proteins encoded by a human DNA virus that inhibit the cGAS-STING DNA sensing pathway, and provides a unique mechanism for the negative regulation of STING-mediated DNA sensing.