Pauline Harawira

TL;DR: The identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer in a large kindred from Aotearoa is described and the important role of E-cadherin mutations in cancer is confirmed.

TL;DR: It is recommended that genetic testing should occur at 16 years of age and that annual surveillance chromogastroscopy also should begin at age 16 in identified CDH-1 mutation carriers, and for individuals younger than 20 years and patients unwilling to undergo prophylactic gastrectomy.

TL;DR: If these findings are validated in other HDGC kindred, chromogastroscopy represents an improved surveillance technique that can be safely considered alongside prophylactic gastrectomy.

TL;DR: It is demonstrated that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori.

TL;DR: In this article, the authors used logistic regression to estimate odd ratios (OR) and 95% confidence intervals (CI) between exposures and stomach cancer risk and found that exposure to environmental tobacco smoke was associated with increased stomach risk.