P
Pauline Macheboeuf
Researcher at University of Grenoble
Publications - 20
Citations - 1384
Pauline Macheboeuf is an academic researcher from University of Grenoble. The author has contributed to research in topics: Penicillin binding proteins & ESCRT. The author has an hindex of 13, co-authored 19 publications receiving 1205 citations. Previous affiliations of Pauline Macheboeuf include Joseph Fourier University & University of California, San Diego.
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Journal ArticleDOI
Penicillin Binding Proteins: key players in bacterial cell cycle and drug resistance processes
TL;DR: Structural, functional and biological features of penicillin-binding proteins, albeit having initially been identified several decades ago, are now being aggressively pursued as highly attractive targets for the development of novel antibiotherapies.
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Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence.
Case W. McNamara,Annelies S. Zinkernagel,Pauline Macheboeuf,Madeleine W. Cunningham,Victor Nizet,Partho Ghosh +5 more
TL;DR: The structure revealed substantial irregularities and instabilities throughout the coiled coil of the M1 fragment as discussed by the authors, explaining the patterns of cross-reactivity seen in autoimmune sequelae of GAS infection.
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Streptococcal M1 protein constructs a pathological host fibrinogen network.
Pauline Macheboeuf,Cosmo Z. Buffalo,Chi-yu Fu,Annelies S. Zinkernagel,Annelies S. Zinkernagel,Jason N. Cole,Jason N. Cole,John E. Johnson,Victor Nizet,Partho Ghosh +9 more
TL;DR: A conformationally dynamic coiled-coil dimer of M1 was found to organize four fibrinogen molecules into a specific cross-like pattern that supported the construction of a supramolecular network that was required for neutrophil activation but was distinct from a fibrIn clot.
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Intrinsic Dynamics in ECFP and Cerulean Control Fluorescence Quantum Yield
Mickaël Lelimousin,Marjolaine Noirclerc-Savoye,Christelle Lazareno-Saez,Bernhard Paetzold,Sophie Le Vot,Richard Chazal,Pauline Macheboeuf,Martin J. Field,Dominique Bourgeois,Dominique Bourgeois,Antoine Royant,Antoine Royant +11 more
TL;DR: The results highlight the considerable dynamical flexibility that exists in the vicinity of the tryptophan-based chromophore of these engineered fluorescent proteins and provide insights that should allow the design of mutants with enhanced optical properties.
Journal ArticleDOI
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins
Pauline Macheboeuf,Anne Marie Di Guilmi,Viviana Job,Thierry Vernet,Otto Dideberg,Andréa Dessen +5 more
TL;DR: The structure of PBP1b* complexed with beta-lactam antibiotics reveals that ligand recognition requires a conformational modification involving conserved elements within the cleft, and suggest how class A PBPs may become activated as novel peptidoglycan synthesis becomes necessary during the cell division process.