P
Pawan Sharma
Researcher at International Centre for Genetic Engineering and Biotechnology
Publications - 40
Citations - 2606
Pawan Sharma is an academic researcher from International Centre for Genetic Engineering and Biotechnology. The author has contributed to research in topics: Mycobacterium tuberculosis & Antigen. The author has an hindex of 22, co-authored 40 publications receiving 2211 citations. Previous affiliations of Pawan Sharma include All India Institute of Medical Sciences & Government of India.
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Journal ArticleDOI
Bioremediation of Heavy Metals from Soil and Aquatic Environment: An Overview of Principles and Criteria of Fundamental Processes
Ruchita Dixit,Wasiullah,Deepti Malaviya,K. Pandiyan,Udai B. Singh,Asha Sahu,Renu Shukla,Bhanu Pratap Singh,Jai P. Rai,Pawan Sharma,Harshad Lade,Diby Paul +11 more
TL;DR: In this article, a review of the abilities of microorganisms and plants in terms of tolerance and degradation of heavy metals is presented, with special reference to the genomics of heavy metal accumulator plants and the identification of functional genes involved in tolerance and detoxification.
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The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Shiny Nair,Poongothai A. Ramaswamy,Sudip Ghosh,Dhananjay C. Joshi,Niteen Pathak,Imran Siddiqui,Pawan Sharma,Seyed E. Hasnain,Shekhar C. Mande,Sangita Mukhopadhyay +9 more
TL;DR: It is demonstrated that one of the PPE proteins, PPE18 can stimulate macrophages to secrete IL-10, known to favor a Th2 type response, and may trigger an anti-inflammatory response by inducing IL- 10 production.
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Early secreted antigen esat-6 of mycobacterium tuberculosis promotes protective t helper 17 cell responses in a toll-like receptor-2-dependent manner
Samit Chatterjee,Ved Prakash Dwivedi,Yogesh Singh,Imran Siddiqui,Pawan Sharma,Luc Van Kaer,Debprasad Chattopadhyay,Gobardhan Das +7 more
TL;DR: Evidence is provided that early secreted antigenic target protein 6 (ESAT-6), expressed by the virulent M. tb strain H37Rv but not by BCG, promotes vaccine-enhancing Th17 cell responses, which indicates that, in addition to Th1 immunity induced byBCG, RD1/ESAT 6-induced Th17 immune responses are essential for optimal vaccine efficacy.
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Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12
Shahin Shafiani,Crystal Dinh,James M. Ertelt,Albanus O. Moguche,Albanus O. Moguche,Imran Siddiqui,Imran Siddiqui,Kate S. Smigiel,Kate S. Smigiel,Pawan Sharma,Daniel J. Campbell,Daniel J. Campbell,Sing Sing Way,Kevin B. Urdahl,Kevin B. Urdahl +14 more
TL;DR: It is shown that pulmonary infection with Mycobacterium tuberculosis (Mtb), but not Listeria monocytogenes (Lm), induced robust lymph node expansion of a highly activated population of pathogen-specific Treg cells from the pre-existing pool of thymically derived TReg cells.
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Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis
Ranjeet Kumar,Priyanka Halder,Sanjaya Kumar Sahu,Manish Kumar,Mandavi Kumari,Kuladip Jana,Zhumur Ghosh,Pawan Sharma,Manikuntala Kundu,Joyoti Basu +9 more
TL;DR: It is observed that the virulence‐associated secreted protein ESAT‐6 plays a key role in miR‐155 induction and its subsequent effects on Bach1 and SHIP1 repression, and the results offer new insights into the role of miRNAs in modulation of the host innate immune response by M.tb.