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Imran Siddiqui
Researcher at University of Lausanne
Publications - 21
Citations - 1964
Imran Siddiqui is an academic researcher from University of Lausanne. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 15, co-authored 21 publications receiving 1286 citations. Previous affiliations of Imran Siddiqui include International Centre for Genetic Engineering and Biotechnology & Seattle Biomed.
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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Imran Siddiqui,Karin Schaeuble,Vijaykumar Chennupati,Silvia A. Fuertes Marraco,Sandra Calderon-Copete,Daniela Pais Ferreira,Santiago J. Carmona,Santiago J. Carmona,Santiago J. Carmona,Leonardo Scarpellino,David Gfeller,David Gfeller,David Gfeller,Sylvain Pradervand,Sanjiv A. Luther,Daniel E. Speiser,Werner Held +16 more
TL;DR: This work identified a subset of tumor‐reactive TILs bearing hallmarks of exhausted cells and central memory cells, including expression of the checkpoint protein PD‐1 and the transcription factor Tcf1 that promote tumor control in response to vaccination and checkpoint blockade immunotherapy.
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The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Shiny Nair,Poongothai A. Ramaswamy,Sudip Ghosh,Dhananjay C. Joshi,Niteen Pathak,Imran Siddiqui,Pawan Sharma,Seyed E. Hasnain,Shekhar C. Mande,Sangita Mukhopadhyay +9 more
TL;DR: It is demonstrated that one of the PPE proteins, PPE18 can stimulate macrophages to secrete IL-10, known to favor a Th2 type response, and may trigger an anti-inflammatory response by inducing IL- 10 production.
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Early secreted antigen esat-6 of mycobacterium tuberculosis promotes protective t helper 17 cell responses in a toll-like receptor-2-dependent manner
Samit Chatterjee,Ved Prakash Dwivedi,Yogesh Singh,Imran Siddiqui,Pawan Sharma,Luc Van Kaer,Debprasad Chattopadhyay,Gobardhan Das +7 more
TL;DR: Evidence is provided that early secreted antigenic target protein 6 (ESAT-6), expressed by the virulent M. tb strain H37Rv but not by BCG, promotes vaccine-enhancing Th17 cell responses, which indicates that, in addition to Th1 immunity induced byBCG, RD1/ESAT 6-induced Th17 immune responses are essential for optimal vaccine efficacy.
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Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12
Shahin Shafiani,Crystal Dinh,James M. Ertelt,Albanus O. Moguche,Albanus O. Moguche,Imran Siddiqui,Imran Siddiqui,Kate S. Smigiel,Kate S. Smigiel,Pawan Sharma,Daniel J. Campbell,Daniel J. Campbell,Sing Sing Way,Kevin B. Urdahl,Kevin B. Urdahl +14 more
TL;DR: It is shown that pulmonary infection with Mycobacterium tuberculosis (Mtb), but not Listeria monocytogenes (Lm), induced robust lymph node expansion of a highly activated population of pathogen-specific Treg cells from the pre-existing pool of thymically derived TReg cells.
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Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity.
Yugang Guo,Yu-Qing Xie,Min Gao,Yang Zhao,Fabien Franco,Fabien Franco,Mathias Wenes,Imran Siddiqui,Alessio Bevilacqua,Alessio Bevilacqua,Haiping Wang,Haiping Wang,Hanshuo Yang,Bing Feng,Xin Xie,Catherine M. Sabatel,Benjamin O. Tschumi,Amphun Chaiboonchoe,Yuxi Wang,Weimin Li,Weihua Xiao,Werner Held,Pedro Romero,Ping-Chih Ho,Ping-Chih Ho,Li Tang +25 more
TL;DR: Findings show that metabolic reprogramming by upregulating mitochondrial pyruvate carrier-dependent OXPHOS can revitalize terminally exhausted T cells and enhance the response to cancer immunotherapy.