S
Sangita Mukhopadhyay
Researcher at Centre for DNA Fingerprinting and Diagnostics
Publications - 72
Citations - 3079
Sangita Mukhopadhyay is an academic researcher from Centre for DNA Fingerprinting and Diagnostics. The author has contributed to research in topics: Mycobacterium tuberculosis & Immune system. The author has an hindex of 28, co-authored 67 publications receiving 2675 citations. Previous affiliations of Sangita Mukhopadhyay include Central Drug Research Institute & Indian Council of Medical Research.
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Journal ArticleDOI
Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway.
Nirupama Silswal,Anil K. Singh,Battu Aruna,Sangita Mukhopadhyay,Sudip Ghosh,Nasreen Z. Ehtesham +5 more
TL;DR: Adding recombinant human resistin protein to macrophages resulted in enhanced secretion of pro-inflammatory cytokines, TNF-alpha and IL-12, similar to that obtained using 5 microg/ml lipopolysaccharide suggesting that the inflammatory action of resistin is independent of its conformation.
Journal ArticleDOI
The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Shiny Nair,Poongothai A. Ramaswamy,Sudip Ghosh,Dhananjay C. Joshi,Niteen Pathak,Imran Siddiqui,Pawan Sharma,Seyed E. Hasnain,Shekhar C. Mande,Sangita Mukhopadhyay +9 more
TL;DR: It is demonstrated that one of the PPE proteins, PPE18 can stimulate macrophages to secrete IL-10, known to favor a Th2 type response, and may trigger an anti-inflammatory response by inducing IL- 10 production.
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PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B-cell response.
Rakesh Kumar Choudhary,Sangita Mukhopadhyay,Prachee Chakhaiyar,Naresh Sharma,K. J. R. Murthy,V. M. Katoch,Seyed E. Hasnain,Seyed E. Hasnain +7 more
TL;DR: The results reveal that this PPE ORF induces a strong B-cell response compared to that generated by M. tuberculosis Hsp10 or PPD, pointing to the immunodominant nature of the protein.
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The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications.
TL;DR: Comparisons of the mouse and human genomic fragments encoding the resistin gene report the presence of a PPAR/RXR heterodimer binding site within intron X (IntX-PPRE) which may possibly confer TZD responsiveness and oligonucleotides carrying the authentic PPar/R XR binding element present in differentiated 3T3-L1 adipocyte cells in an electrophoretic mobility shift assay.
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The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: Perhaps more?
TL;DR: The PE/PPE multigene family codes for approximately 10% of the Mycobacterium tuberculosis proteome and is encoded by 176 open reading frames and has a conserved structure and repeat motifs that could be a potential source of antigenic variation in M. tuberculosis.