Pawlos S. Tsegay

TL;DR: This review describes the main recent achievements in the preparation of the cPu molecular library for analytical and DNA synthesis applications for the studies of the enzymatic recognition and repair mechanisms, their impact on transcription and genetic instability, and quantitative determination of the levels of lesions in various types of cells and animal model systems.

TL;DR: This review summarizes DNA damage-induced replication stress, the formation of DNA secondary structures, peculiar epigenetic modifications and cellular responses to the stress and their impact on the instability of the genome and epigenome mainly in eukaryotic cells.

TL;DR: This study provides the first evidence that oxidative DNA damage can cause dynamic changes inDNA methylation in the BRCA1 gene through the crosstalk between BER and de novo DNA methylation.

TL;DR: This study provides direct evidence that oxidative DNA damage disrupted human cell membrane integrity by deregulating cytoskeleton gene expression.

TL;DR: In this paper, the authors examined the incorporation of 5',8-cyclo-2'-deoxyadenosine (cdA) by human DNA repair polymerases, and determined the efficiency of cdA incorporation by the polymerases using steady-state kinetics.