Pei Gao

TL;DR: It is indicated that genetically diverse viruses circulate in LBMs in South China's Guangdong Province and that NDV from different birds have different tissue tropisms and host ranges when transmitted in different birds.

TL;DR: Results show distinct expression patterns of cytokines, Toll-like receptors and IFNs associated with inflammatory immune responses to NDV between species and by virulence.

TL;DR: It is demonstrated that apoptosis inhibition enhances autophagy and promoted cell survival and NDV replication and cell viability by inhibiting apoptosis.

TL;DR: It is demonstrated that NDV transiently activates the PI3K/Akt pathway in chicken cells at an early phase of infection, and the pan caspase inhibitor ZVAD-FMK mitigated the reduction in Akt phosphorylation by inhibitingPI3K activation, which indicates the signaling pathway promotes cell survival and, in turn, facilitates viral replication.

TL;DR: The GM strain triggered stronger innate immune responses than the La Sota strain in chicken BM-DCs, and both strains were able to suppress the expression of some cytokines at 24 hpi, which provide a foundation for further investigation of the role of chicken DCs in NDV infection.