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Pei Jung Lu
Researcher at National Cheng Kung University
Publications - 91
Citations - 3683
Pei Jung Lu is an academic researcher from National Cheng Kung University. The author has contributed to research in topics: Cancer & Phosphorylation. The author has an hindex of 30, co-authored 91 publications receiving 3214 citations. Previous affiliations of Pei Jung Lu include Kaohsiung Medical University & National Defense Medical Center.
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Journal ArticleDOI
MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation
TL;DR: This is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR -330 induces apoptosis in prostate cancer cells through E1F1-mediated suppression of Akt phosphorylation.
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MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway
I-Shan Hsieh,Kung Chao Chang,Yao Tsung Tsai,Jhen-Yu Ke,Pei Jung Lu,Kuen Haur Lee,Shauh-Der Yeh,Tse-Ming Hong,Yuh Ling Chen +8 more
TL;DR: Results support that miR-320 is a key negative regulator in prostate TICs, and suggest developing mi R-320 as a novel therapeutic agent may offer benefits for PCa treatment.
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Cisplatin Selects for Multidrug-Resistant CD133+ Cells in Lung Adenocarcinoma by Activating Notch Signaling
Yu Peng Liu,Chih Jen Yang,Ming Shyan Huang,Chi Tai Yeh,Alexander T.H. Wu,Yu Cheng Lee,Tsung Ching Lai,Chien Hsin Lee,Ya Wen Hsiao,Jean Lu,Chia-Ning Shen,Pei Jung Lu,Michael Hsiao +12 more
TL;DR: It is revealed that CD133(+) lung cancer cells labeled by a human CD133 promoter-driven GFP reporter exhibited drug resistance and stem cell characteristics, leading to multidrug resistance by the activation of Notch signaling.
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Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer
Chi Tai Yeh,Chi Tai Yeh,Alexander T.H. Wu,Alexander T.H. Wu,Peter Mu Hsin Chang,Kuan-Yu Chen,Chia Ning Yang,Shuenn Chen Yang,Chao-Chi Ho,Chun-Chi Chen,Yu-Lun Kuo,Pei Ying Lee,Yu-Wen Liu,Chueh Chuan Yen,Michael Hsiao,Pei Jung Lu,Jin Mei Lai,Liang Shun Wang,Chih Hsiung Wu,Jeng Fong Chiou,Pan-Chyr Yang,Pan-Chyr Yang,Chi Ying F. Huang +22 more
TL;DR: An existing phenothiazine-like antipsychotic drug, trifluoperazine, is repurposed as a potential anti-CSC agent that could overcome epidermal growth factor receptor-tyrosine kinase inhibitor and chemotherapy resistance in patients with lung cancer.
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MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.
Kuen Haur Lee,Yih Gang Goan,Michael Hsiao,Chien Hsing Lee,Shu Huei Jian,Jen Tai Lin,Yuh Ling Chen,Pei Jung Lu +7 more
TL;DR: It is shown that miR-373 would be a potential oncogene and it participates in the carcinogenesis of human esophageal cancer by suppressing LATS2 expression and this correlation was supported by data collected ex vivo, in which esophagal cancer tissues from esphageal squamous cell carcinoma patients were analyzed.