K
Kuan-Yu Chen
Researcher at National Taiwan University
Publications - 158
Citations - 5530
Kuan-Yu Chen is an academic researcher from National Taiwan University. The author has contributed to research in topics: Lung cancer & Adenocarcinoma. The author has an hindex of 39, co-authored 144 publications receiving 4807 citations. Previous affiliations of Kuan-Yu Chen include AU Optronics & Academia Sinica.
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Journal ArticleDOI
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
Qing Lan,Chao A. Hsiung,Keitaro Matsuo,Yun Chul Hong,Adeline Seow,Zhaoming Wang,H. Dean Hosgood,H. Dean Hosgood,Kexin Chen,Jiucun Wang,Nilanjan Chatterjee,Wei Hu,Maria Pik Wong,Wei Zheng,Neil E. Caporaso,Jae Yong Park,Chien-Jen Chen,Yeul Hong Kim,Young Tae Kim,Maria Teresa Landi,Hongbing Shen,Charles E. Lawrence,Laurie Burdett,Meredith Yeager,Jeffrey Yuenger,Kevin B. Jacobs,I. Shou Chang,Tetsuya Mitsudomi,Hee Nam Kim,Gee-Chen Chang,Bryan A. Bassig,Bryan A. Bassig,Margaret A. Tucker,Fusheng Wei,Zhihua Yin,Chen Wu,She-Juan An,Biyun Qian,Victor Ho Fun Lee,Daru Lu,Jianjun Liu,Jianjun Liu,Hyo Sung Jeon,Chin-Fu Hsiao,Jae Sook Sung,Jin Hee Kim,Yu Tang Gao,Ying-Huang Tsai,Yoo Jin Jung,Huan Guo,Zhibin Hu,Amy Hutchinson,Wen Chang Wang,Robert J. Klein,Charles C. Chung,In-Jae Oh,Kuan-Yu Chen,Sonja I. Berndt,Xingzhou He,Wei Wu,Jiang Chang,X. Zhang,Ming Shyan Huang,Hong Zheng,Junwen Wang,Xueying Zhao,Yuqing Li,Jin Eun Choi,Wu Chou Su,Kyong Hwa Park,Sook Whan Sung,Xiao-Ou Shu,Yuh Min Chen,Li Liu,Chang Hyun Kang,Lingmin Hu,Chung Hsing Chen,William Pao,Young-Chul Kim,Tsung-Ying Yang,Jun Xu,Peng Guan,Wen Tan,Jian Su,Chih-Liang Wang,Haixin Li,Alan D. L. Sihoe,Zhenhong Zhao,Ying Chen,Yi Young Choi,Jen Yu Hung,Jun Suk Kim,Ho Il Yoon,Qiuyin Cai,Chien Chung Lin,In Kyu Park,Ping Xu,Jing Dong,Christopher Kim,Qincheng He,Reury Perng Perng,Takashi Kohno,Sun-Seog Kweon,Chih Yi Chen,Roel Vermeulen,Junjie Wu,Wei-Yen Lim,Kun-Chieh Chen,Wong Ho Chow,Bu Tian Ji,John K.C. Chan,Minjie Chu,Yao Jen Li,Jun Yokota,Jihua Li,Hongyan Chen,Yong-Bing Xiang,Chong-Jen Yu,Hideo Kunitoh,Guoping Wu,Li Jin,Yen Li Lo,Kouya Shiraishi,Ying Hsiang Chen,HC Lin,Tangchun Wu,Yi-Long Wu,Pan-Chyr Yang,Baosen Zhou,Min-Ho Shin,Joseph F. Fraumeni,Dongxin Lin,Stephen J. Chanock,Nathaniel Rothman +133 more
TL;DR: It is observed that there is no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.
Journal ArticleDOI
Pulmonary Sequelae in Convalescent Patients after Severe Acute Respiratory Syndrome: Evaluation with Thin-Section CT
Yeun-Chung Chang,Chong-Jen Yu,Shan-Chwen Chang,Jeffrey R. Galvin,Hon-Man Liu,Cheng-Hsiang Hsiao,Ping-Hong Kuo,Kuan-Yu Chen,Teri J. Franks,Kou-Mou Huang,Pan-Chyr Yang +10 more
TL;DR: Thin-section CT scores correlated with clinical and laboratory parameters in patients after SARS, and it is concluded that ground-glass opacity and interstitial opacity resolve over time, air trapping persists.
Journal ArticleDOI
Specific EGFR Mutations Predict Treatment Outcome of Stage IIIB/IV Patients With Chemotherapy-Naive Non–Small-Cell Lung Cancer Receiving First-Line Gefitinib Monotherapy
Chih-Hsin Yang,Chong-Jen Yu,Jin-Yuan Shih,Yeun-Chung Chang,Fu-Chang Hu,Meng-Chin Tsai,Kuan-Yu Chen,Zhong-Zhe Lin,Ching-Ju Huang,Chia-Tung Shun,Chin-Lun Huang,Jonathan F. Bean,Ann-Lii Cheng,William Pao,Pan-Chyr Yang +14 more
TL;DR: In this prospective study, EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy.
Journal ArticleDOI
The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia
Chao A. Hsiung,Qing Lan,Yun Chul Hong,Chien-Jen Chen,Chien-Jen Chen,Iii Dean Hosgood,I. Shou Chang,Nilanjan Chatterjee,Paul Brennan,Chen Wu,Wei Zheng,Gee-Chen Chang,Gee-Chen Chang,Tangchun Wu,Jae Yong Park,Chin-Fu Hsiao,Yeul Hong Kim,Hongbing Shen,Adeline Seow,Meredith Yeager,Ying-Huang Tsai,Young Tae Kim,Wong Ho Chow,Huan Guo,Wen Chang Wang,Sook Whan Sung,Zhibin Hu,Kuan-Yu Chen,Joohyun Kim,Ying Chen,Liming Huang,Kyoung Mu Lee,Yen Li Lo,Yu Tang Gao,Jin Hee Kim,Li Liu,Ming Shyan Huang,Tae Hoon Jung,Guangfu Jin,Neil E. Caporaso,Dianke Yu,Chang Ho Kim,Wu Chou Su,Xiao-Ou Shu,Ping Xu,In San Kim,Yuh Min Chen,Hongxia Ma,Min Shen,Sung Ick Cha,Wen Tan,Chin-Hao Chang,Jae Sook Sung,Mingfeng Zhang,Tsung-Ying Yang,Kyong Hwa Park,Jeff Yuenger,Chih-Liang Wang,Jeong Seon Ryu,Yong-Bing Xiang,Qifei Deng,Amy Hutchinson,Jun Suk Kim,Qiuyin Cai,Maria Teresa Landi,Chong-Jen Yu,Ju Yeon Park,Margaret A. Tucker,Jen Yu Hung,Chien Chung Lin,Reury Perng Perng,Paolo Boffetta,Chih Yi Chen,Kun-Chieh Chen,Shi Yi Yang,Chi Yuan Hu,Chung Kai Chang,Joseph F. Fraumeni,Stephen J. Chanock,Pan-Chyr Yang,Nathaniel Rothman,Dongxin Lin +81 more
TL;DR: Results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.
Journal ArticleDOI
Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer
Chi Tai Yeh,Chi Tai Yeh,Alexander T.H. Wu,Alexander T.H. Wu,Peter Mu Hsin Chang,Kuan-Yu Chen,Chia Ning Yang,Shuenn Chen Yang,Chao-Chi Ho,Chun-Chi Chen,Yu-Lun Kuo,Pei Ying Lee,Yu-Wen Liu,Chueh Chuan Yen,Michael Hsiao,Pei Jung Lu,Jin Mei Lai,Liang Shun Wang,Chih Hsiung Wu,Jeng Fong Chiou,Pan-Chyr Yang,Pan-Chyr Yang,Chi Ying F. Huang +22 more
TL;DR: An existing phenothiazine-like antipsychotic drug, trifluoperazine, is repurposed as a potential anti-CSC agent that could overcome epidermal growth factor receptor-tyrosine kinase inhibitor and chemotherapy resistance in patients with lung cancer.