Pengda Chen

TL;DR: It is reported that gasdermin D (GSDMD) is another crucial component of inflammasomes and the presence of GSDMD protein in nigericin-induced NLRP3 inflammaomes is discovered by a quantitative mass spectrometry-based analysis.

TL;DR: Deletion analysis showed that the four-α-helix bundle of MLKL (1-130 amino acids) is sufficient to trigger necroptosis and the homo-oligomerization is required for MLKKL translocation and the signal sequence for plasma membrane location is located in the junction of the first and second α-helices ofMLKL.

TL;DR: This study found that transgenic mice overexpressing miR-17~92 specifically in epithelial cells of the small and large intestines exhibited decreased tumor size and tumor angiogenesis in azoxymethane and dextran sulfate sodium salt-induced CRC model as compared to their littermates control.

TL;DR: An integrated analysis of transcriptome and translatome of primary B cells from mutant mice expressing miR-17~92 at three different levels found that target genes exhibit differential sensitivity to miRNA suppression and that only a small fraction of target genes are actually suppressed by a given concentration of miRNA under physiological conditions.

TL;DR: New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context and cell-type-specific regulation by transcription factors is a fundamental principle of biology.