Changchun Xiao

TL;DR: It is shown that the evolutionarily conserved microRNA-155 has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response.

TL;DR: The genomic region encoding the miR-17-92 microRNA (miRNA) cluster is often amplified in lymphoma and other cancers, and cancer cells carrying this amplification have higher expression of miRNA in this cluster, and this mechanism probably contributed to the lymphoproliferative disease and autoimmunity ofmiR- 17-92-transgenic mice and contributes to lymphoma development in patients with amplifications of this coding region.

TL;DR: MicroRNA (miRNA) control has emerged as a critical regulatory principle in the mammalian immune system and severely compromises immune development and response and can lead to immune disorders like autoimmunity and cancer.

TL;DR: It is shown that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c- myb concentrations and that this dramatically affects lymphocyte development and response.

TL;DR: The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways.