Wan-ting He

TL;DR: It is reported that gasdermin D (GSDMD) is another crucial component of inflammasomes and the presence of GSDMD protein in nigericin-induced NLRP3 inflammaomes is discovered by a quantitative mass spectrometry-based analysis.

TL;DR: A role for potent neutralizing antibodies (nAbs) in prophylaxis, and potentially therapy, of COVID-19 is suggested, as indicated by maintained weight and low lung viral titers in treated animals, and the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters.

TL;DR: Deletion analysis showed that the four-α-helix bundle of MLKL (1-130 amino acids) is sufficient to trigger necroptosis and the homo-oligomerization is required for MLKKL translocation and the signal sequence for plasma membrane location is located in the junction of the first and second α-helices ofMLKL.

TL;DR: It is shown that N-terminal fragment of GSDMD (GSDMD-N) generated by caspase cleavage also forms oligomer and migrates to the plasma membrane to kill cells and determines different ways of plasma membrane rupture in pyroptosis and necroptosis.

TL;DR: It is shown that in response to inflammasome activators, MAMs localize adjacent to Golgi membranes, and Golgi-mediated PKD signaling is required and sufficient for NLRP3 inflammaome activation.